T
Torsten Rülker
Researcher at Braunschweig University of Technology
Publications - 6
Citations - 292
Torsten Rülker is an academic researcher from Braunschweig University of Technology. The author has contributed to research in topics: Alphavirus & Venezuelan equine encephalitis virus. The author has an hindex of 4, co-authored 6 publications receiving 279 citations.
Papers
More filters
Journal ArticleDOI
A human scFv antibody generation pipeline for proteome research
Michael Hust,Torsten Meyer,Bernd Voedisch,Torsten Rülker,Holger Thie,Aymen El-Ghezal,Martina Inga Kirsch,Mark Schütte,Saskia Helmsing,Doris Meier,Thomas Schirrmann,Stefan Dübel +11 more
TL;DR: This work presents the first comprehensive comparison of V gene subfamily use for all steps of an antibody phage display pipeline, and describes a compatible cassette vector set, allowing in vivo biotinylation, enzyme fusion and Fc fusion.
Journal ArticleDOI
Development of human antibody fragments using antibody phage display for the detection and diagnosis of Venezuelan equine encephalitis virus (VEEV)
Martina Inga Kirsch,Birgit Hülseweh,Christoph Nacke,Torsten Rülker,Thomas Schirrmann,Hans-Jürgen Marschall,Michael Hust,Stefan Dübel +7 more
TL;DR: The selection of antibodies against a human pathogenic virus from a human naïve scFv antibody gene library using complete, active virus particles as antigen will improve the fast identification of VEEV in case of a biological warfare or terroristic attack or a natural outbreak.
Journal ArticleDOI
Isolation and Characterisation of a Human-Like Antibody Fragment (scFv) That Inactivates VEEV In Vitro and In Vivo
Torsten Rülker,Luzie Voß,Philippe Thullier,Lyn M. O' Brien,Thibaut Pelat,Stuart D. Perkins,Claudia Langermann,Thomas Schirrmann,Stefan Dübel,Hans-Jürgen Marschall,Michael Hust,Birgit Hülseweh +11 more
TL;DR: The isolation of the anti-VEEV single chain Fragment variable (scFv), ToR67-3B4, from a non-human primate (NHP) antibody gene library is described and its recloning into the bivalent scFv-Fc format and further immunological and biochemical characterisation are reported.
Journal ArticleDOI
Human-like antibodies neutralizing Western equine encephalitis virus
Birgit Hülseweh,Torsten Rülker,Thibaut Pelat,Claudia Langermann,André Frenzel,Thomas Schirrmann,Stefan Dübel,Philippe Thullier,Michael Hust +8 more
TL;DR: The development of the first neutralizing antibodies against Western equine encephalitis virus (WEEV), a member of the genus Alphavirus, is described, which is a promising candidate for future passive vaccine development.