T
Toru Akune
Researcher at University of Tokyo
Publications - 131
Citations - 8229
Toru Akune is an academic researcher from University of Tokyo. The author has contributed to research in topics: Population & Odds ratio. The author has an hindex of 43, co-authored 120 publications receiving 6965 citations. Previous affiliations of Toru Akune include Wakayama Medical University.
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Journal ArticleDOI
PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
Toru Akune,Shinsuke Ohba,Satoru Kamekura,Masayuki Yamaguchi,Ung-il Chung,Naoto Kubota,Yasuo Terauchi,Yoshifumi Harada,Yoshiaki Azuma,Kozo Nakamura,Takashi Kadowaki,Hiroshi Kawaguchi +11 more
TL;DR: A PPARgamma-dependent regulation of bone metabolism in vivo is demonstrated, in that PPargamma insufficiency increases bone mass by stimulating osteoblastogenesis from bone marrow progenitors.
Journal ArticleDOI
Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study.
Noriko Yoshimura,Shigeyuki Muraki,Hiroyuki Oka,Akihiko Mabuchi,Yoshio Enyo,Munehito Yoshida,Akihiko Saika,Hideyo Yoshida,Takao Suzuki,Seizo Yamamoto,Hideaki Ishibashi,Hiroshi Kawaguchi,Kozo Nakamura,Toru Akune +13 more
TL;DR: The ROAD study will elucidate epidemiological evidence concerning determinants of bone and joint disease by estimating the prevalence of OA and OP, and the number of people affected with these diseases in Japan.
Journal ArticleDOI
Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
Taku Saito,Atsushi Fukai,Akihiko Mabuchi,Toshiyuki Ikeda,Fumiko Yano,Shinsuke Ohba,Nao Nishida,Toru Akune,Noriko Yoshimura,Takumi Nakagawa,Kozo Nakamura,Katsushi Tokunaga,Ung-il Chung,Hiroshi Kawaguchi +13 more
TL;DR: In this paper, a hypoxia-inducible factor-2alpha (HIF-2α) encoded by EPAS1 was identified as the most potent transactivator of COL10A1, which was essential for endochondral ossification of cultured chondrocytes and embryonic skeletal growth in mice.
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Long-term results of double-door laminoplasty for cervical stenotic myelopathy.
Atsushi Seichi,Katsushi Takeshita,Isao Ohishi,Hiroshi Kawaguchi,Toru Akune,Yorito Anamizu,Tomoaki Kitagawa,Kozo Nakamura +7 more
TL;DR: The short-term results of laminoplasty for cervical stenotic myelopathy were maintained over 10years in 78% of the patients with ossification of the posterior longitudinal ligament, and in most of the customers with cervical spondylosis, except those with athetoid cerebral palsy.
Journal ArticleDOI
Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: The ROAD study
Shigeyuki Muraki,Hiroyuki Oka,Toru Akune,Akihiko Mabuchi,Yoshio Enyo,Munehito Yoshida,Akihiko Saika,T. Suzuki,H. Yoshida,Hideaki Ishibashi,S. Yamamoto,Kozo Nakamura,Hiroshi Kawaguchi,Noriko Yoshimura +13 more
TL;DR: Knee pain was strongly associated with JSN especially in men, while women tended to have knee pain even without radiographic OA, and the association was higher in men than in women.