Taku Saito

TL;DR: In this paper, a hypoxia-inducible factor-2alpha (HIF-2α) encoded by EPAS1 was identified as the most potent transactivator of COL10A1, which was essential for endochondral ossification of cultured chondrocytes and embryonic skeletal growth in mice.

TL;DR: The molecular network found in this study will provide a basis for rational therapeutic targets for bone disorders and a novel role of Akt1/forkhead box class O (FoxO) 3a/Bim axis in the apoptosis of osteoblasts is revealed.

TL;DR: It is indicated that NF-κB/TNF-α signaling in LICs contributes to leukemia progression and provides a widely applicable approach for targeting LICs.

TL;DR: Gremlin-1 is identified as a mechanical loading-inducible factor in chondrocytes, detected at high levels in middle and deep layers of cartilage after cyclic strain or hydrostatic pressure loading, and contributing to osteoarthritis via activation of the NF-κB pathway.

TL;DR: The RBPjκ-dependent Notch signaling in chondrocytes modulates the terminal stage of endochondral ossification and OA development, representing an extracellular therapeutic target of OA.