T
Toru Hamada
Researcher at Jichi Medical University
Publications - 15
Citations - 2530
Toru Hamada is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Complementary DNA & EML4/ALK Fusion Gene. The author has an hindex of 9, co-authored 15 publications receiving 2399 citations.
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Journal ArticleDOI
EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
Young Lim Choi,Manabu Soda,Yoshihiro Yamashita,Toshihide Ueno,Junpei Takashima,Takahiro Nakajima,Yasushi Yatabe,Kengo Takeuchi,Toru Hamada,Hidenori Haruta,Yuichi Ishikawa,Hideki Kimura,Tetsuya Mitsudomi,Yoshiro Tanio,Hiroyuki Mano +14 more
TL;DR: The discovery of two secondary mutations within the kinase domain of EML4-ALK in tumor cells isolated from a patient during the relapse phase of treatment with an ALK inhibitor are reported.
Journal ArticleDOI
A mouse model for EML4-ALK-positive lung cancer
Manabu Soda,Shuji Takada,Kengo Takeuchi,Young Lim Choi,Munehiro Enomoto,Toshihide Ueno,Hidenori Haruta,Toru Hamada,Yoshihiro Yamashita,Yuichi Ishikawa,Yukihiko Sugiyama,Hiroyuki Mano +11 more
TL;DR: The established transgenic mouse lines that express EML4-ALK specifically in lung alveolar epithelial cells reinforce the pivotal role of EML 4-ALK in the pathogenesis of NSCLC in humans and provide experimental support for the treatment of this intractable cancer with ALK inhibitors.
Journal ArticleDOI
Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer
Young Lim Choi,Kengo Takeuchi,Manabu Soda,Kentaro Inamura,Yuki Togashi,Satoko Hatano,Munehiro Enomoto,Toru Hamada,Hidenori Haruta,Hideki Watanabe,Kentaro Kurashina,Hisashi Hatanaka,Toshihide Ueno,Shuji Takada,Yoshihiro Yamashita,Yukihiko Sugiyama,Yuichi Ishikawa,Hiroyuki Mano +17 more
TL;DR: Two slightly different fusion cDNAs in which exon 6 of EML4 was joined to exon 20 of ALK were each identified in two individuals of the cohort and exhibited marked transforming activity in vitro as well as oncogenic activity in vivo.
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Array-based genomic resequencing of human leukemia
Yoshihiro Yamashita,J Yuan,Isao Suetake,Hiromu Suzuki,Yuichi Ishikawa,Young Lim Choi,Young Lim Choi,Toshihide Ueno,Manabu Soda,Toru Hamada,Hidenori Haruta,Shuji Takada,Yasushi Miyazaki,Hitoshi Kiyoi,Etsuro Ito,Tomoki Naoe,M Tomonaga,Minoru Toyota,Shoji Tajima,Atsushi Iwama,Hiroyuki Mano,Hiroyuki Mano +21 more
TL;DR: The data have shown a unique profile of gene mutations in human leukemia, and a somatic change responsible for an Arg-to-His substitution at amino-acid position 882 of DNA methyltransferase 3A, which resulted in a loss ofDNA methylation activity of >50%.
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Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinoma.
Kentaro Kurashina,Yoshihiro Yamashita,Toshihide Ueno,Koji Koinuma,Jun Ohashi,Hisanaga Horie,Yasuyuki Miyakura,Toru Hamada,Hidenori Haruta,Hisashi Hatanaka,Manabu Soda,Young Lim Choi,Shuji Takada,Yoshikazu Yasuda,Hideo Nagai,Hiroyuki Mano +15 more
TL;DR: The precise and large‐scale measurement of CNA and LOH in the CRC genome is efficient for pinpointing prognosis‐related genome regions as well as providing a list of unknown genes that are likely to be involved in CRC development.