Y
Yukihiko Sugiyama
Researcher at Jichi Medical University
Publications - 191
Citations - 11823
Yukihiko Sugiyama is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Bronchoalveolar lavage. The author has an hindex of 40, co-authored 189 publications receiving 10464 citations.
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Journal ArticleDOI
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
Manabu Soda,Young Lim Choi,Munehiro Enomoto,Shuji Takada,Yoshihiro Yamashita,Shunpei Ishikawa,Shin-ichiro Fujiwara,Hideki Watanabe,Kentaro Kurashina,Hisashi Hatanaka,Masashi Bando,Shoji Ohno,Yuichi Ishikawa,Hiroyuki Aburatani,Toshiro Niki,Yasunori Sohara,Yukihiko Sugiyama,Hiroyuki Mano +17 more
TL;DR: It is shown that a small inversion within chromosome 2p results in the formation of a fusion gene comprising portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene and the anaplastic lymphoma kinase (ALK) gene in non-small-cell lung cancer (NSCLC) cells.
Journal ArticleDOI
A mouse model for EML4-ALK-positive lung cancer
Manabu Soda,Shuji Takada,Kengo Takeuchi,Young Lim Choi,Munehiro Enomoto,Toshihide Ueno,Hidenori Haruta,Toru Hamada,Yoshihiro Yamashita,Yuichi Ishikawa,Yukihiko Sugiyama,Hiroyuki Mano +11 more
TL;DR: The established transgenic mouse lines that express EML4-ALK specifically in lung alveolar epithelial cells reinforce the pivotal role of EML 4-ALK in the pathogenesis of NSCLC in humans and provide experimental support for the treatment of this intractable cancer with ALK inhibitors.
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Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer
Young Lim Choi,Kengo Takeuchi,Manabu Soda,Kentaro Inamura,Yuki Togashi,Satoko Hatano,Munehiro Enomoto,Toru Hamada,Hidenori Haruta,Hideki Watanabe,Kentaro Kurashina,Hisashi Hatanaka,Toshihide Ueno,Shuji Takada,Yoshihiro Yamashita,Yukihiko Sugiyama,Yuichi Ishikawa,Hiroyuki Mano +17 more
TL;DR: Two slightly different fusion cDNAs in which exon 6 of EML4 was joined to exon 20 of ALK were each identified in two individuals of the cohort and exhibited marked transforming activity in vitro as well as oncogenic activity in vivo.
Journal ArticleDOI
Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation.
Katsuhisa Oshikawa,Kenji Kuroiwa,Kenji Tago,Hiroyuki Iwahana,Ken Yanagisawa,Shoji Ohno,Shin-ichi Tominaga,Yukihiko Sugiyama +7 more
TL;DR: The results suggest that soluble human ST2 protein in sera may be related to Th2-mediated allergic inflammation inducing acute exacerbation in patients with atopic asthma.
Journal ArticleDOI
Epidemiologic Survey of Japanese Patients with Idiopathic Pulmonary Fibrosis and Investigation of Ethnic Differences
Motoki Natsuizaka,Hirofumi Chiba,Koji Kuronuma,Mitsuo Otsuka,Kazumi Kudo,Mitsuru Mori,Masashi Bando,Yukihiko Sugiyama,Hiroki Takahashi +8 more
TL;DR: The results showed that in men, the incidence of death caused by acute exacerbation was higher and that caused by cardiovascular disease was lower in Japan than in Western countries, which may suggest ethnic differences in IPF.