Toshiaki Kodama

TL;DR: An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation and defines a system for molecular dissection of the determinants of AIDS pathogenesis.

TL;DR: Results indicate that vaccination with inactivated whole virus can protect macaques against challenge with live SIV, and provide hope that vaccine protection against human AIDS virus infection may be possible.

TL;DR: Although profound depletion of tissue CD4+ memory T cells appeared to be a prerequisite for early pathogenesis, it was the inability to respond to this depletion with sustained production of tissue-homing CD4-memory T cells that best distinguished rapid progressors, suggesting that mechanisms of the CD4+, memory T cell generation play a crucial role in maintaining immune homeostasis in stable SIV infection.

TL;DR: The location of the translational termination codon for the transmembrane protein (TMP) varies in three infectious molecular clones of simian immunodeficiency virus from macaques (SIVmac) as mentioned in this paper.

TL;DR: The emergence of macrophagetropic variants in vivo was associated with specific pathologic manifestations in which the macrophage is the major infected cell type, and the presence ofmacrophage-tropic virus variant in vivo can influence the disease course and disease manifestations.