T
Toshihiro Kawamoto
Researcher at University of Occupational and Environmental Health Japan
Publications - 6
Citations - 490
Toshihiro Kawamoto is an academic researcher from University of Occupational and Environmental Health Japan. The author has contributed to research in topics: Aldehyde dehydrogenase & ALDH2. The author has an hindex of 5, co-authored 6 publications receiving 471 citations.
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Journal ArticleDOI
Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse.
Kyoko Kitagawa,Toshihiro Kawamoto,Naoki Kunugita,Tadasuke Tsukiyama,Kohji Okamoto,Akira Yoshida,Keiko Nakayama,Keiichi I. Nakayama +7 more
TL;DR: In vitro MALD oxidation was examined with liver subcellular fractions from Japanese subjects who carried three different ALDH2 genotypes and Aldh2 knockout mice, which suggest that ALDH 2 is a key enzyme for Mald oxidation and ME susceptibility may be influenced by the AL DH2 genotype.
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Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer
Takahiko Katoh,Shigeru Kaneko,Kiyotaka Kohshi,Masahiro Munaka,Kyoko Kitagawa,Naoki Kunugita,Kunio Ikemura,Toshihiro Kawamoto +7 more
TL;DR: The results imply that the GSTM1 null genotype has a weak correlation, but another 4 genetic polymorphisms are unlikely to be associated, with oral cavity cancer among Japanese.
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Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity.
Toyohi Isse,Tsunehiro Oyama,Kyoko Kitagawa,Koji Matsuno,Akiko Matsumoto,Akira Yoshida,Keiko Nakayama,Keiichi I. Nakayama,Toshihiro Kawamoto +8 more
TL;DR: Results indicate that a direct effect of the Aldh2 genotype plays an important role on alcohol preference and acetaldehyde concentration in the brain is correlated with alcohol avoidance, and highlights the potential benefits of alcoholism and alcohol-related disease research in the animal model of ALDH2 alleles.
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Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver.
TL;DR: The results suggest that the single nucleotide polymorphisms of the ALDH2 gene only alter the metabolism of aldehydes with a short aliphatic chain, and sex, drinking alcohol, and smoking had little effect on ALDH activity, although the activity in elderly individuals tended to be lower albeit statistically insignificant.
Journal Article
Individual differences in urinary cotinine levels in Japanese smokers: relation to genetic polymorphism of drug-metabolizing enzymes.
Mihi Yang,Naoki Kunugita,Kyoko Kitagawa,Seung Ho Kang,Brian F. Coles,Fred F. Kadlubar,Takahiko Katoh,Koji Matsuno,Toshihiro Kawamoto +8 more
TL;DR: The number of cigarettes smoked and CYP2A6 polymorphism were significantly associated with the urinary cotinine level and polymorphisms in CYP1A1 or ALDH2, and consumption of alcohol, coffee, or tea were not associated with that level.