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Keiko Nakayama
Researcher at Kyushu University
Publications - 71
Citations - 11751
Keiko Nakayama is an academic researcher from Kyushu University. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 43, co-authored 58 publications receiving 11418 citations. Previous affiliations of Keiko Nakayama include Tohoku University & Washington University in St. Louis.
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Journal ArticleDOI
Mice Lacking p27Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors
Keiko Nakayama,Keiko Nakayama,Noriko Ishida,Michiko Shirane,Akira Inomata,Tomoaki Inoue,Nobuyuki Shishido,Ikuo Horii,Dennis Y. Loh,Dennis Y. Loh,Keiichi I. Nakayama,Keiichi I. Nakayama +11 more
TL;DR: Findings indicate that p27(Kip1) acts to regulate the growth of a variety of cells, and surprises us by keeping the cell cycle arrest mediated by TGFbeta, rapamycin, or contact inhibition intact in p27(-/-) cells.
Journal ArticleDOI
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
Noboru Motoyama,Fanping Wang,Kevin A. Roth,Hirofumi Sawa,Keiichi I. Nakayama,Keiko Nakayama,Izumi Negishi,Satoru Senju,Qing Zhang,S Fujii,Dennis Y. Loh +10 more
TL;DR: Analyses of bcl-x double-knockout chimeric mice showed that the maturation of B cl-x-deficient lymphocytes was diminished and the life-span of immature lymph cells, but not mature lymphocytes, was shortened.
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Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication
Keiko Nakayama,Hiroyasu Nagahama,Yohji A. Minamishima,Masaki Matsumoto,Ikuo Nakamichi,Kyoko Kitagawa,Michiko Shirane,Ryosuke Tsunematsu,Tadasuke Tsukiyama,Noriko Ishida,Masatoshi Kitagawa,Keiichi I. Nakayama,Shigetsugu Hatakeyama +12 more
TL;DR: Results suggest that specific degradation of cyclin E and p27Kip1 is mediated by the SCFSkp2 ubiquitin ligase complex, and that Skp2 may control chromosome replication and centrosome duplication by determining the abundance of cell cycle regulators.
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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
Masatoshi Kitagawa,Shigetsugu Hatakeyama,Michiko Shirane,Masaki Matsumoto,Noriko Ishida,Kimihiko Hattori,Ikuo Nakamichi,Akira Kikuchi,Keiichi I. Nakayama,Keiko Nakayama +9 more
TL;DR: Results suggest that the Skp1/Cullin/F‐box protein FWD1 (SCFFWD1)–ubiquitin ligase complex is involved in β‐catenin ubiquitination and that FWD 1 serves as an intracellular receptor for phosphorylated β‐ catenin.
Journal ArticleDOI
Essential role for ZAP-70 in both positive and negative selection of thymocytes
Izumi Negishi,Izumi Negishi,Izumi Negishi,Noboru Motoyama,Keiichi I. Nakayama,Keiichi I. Nakayama,Keiichi I. Nakayama,Keiko Nakayama,Keiko Nakayama,Keiko Nakayama,Satoru Senju,Shigetsugu Hatakeyama,Qing Zhang,Andrew C. Chan,Dennis Y. Loh,Dennis Y. Loh,Dennis Y. Loh +16 more
TL;DR: The data suggest that ZAP-70 is a central signalling molecule during thymic selection for CD4 and CD8 lineage, and that natural killer cell function was intact in the absence of Zap-70.