Toshihiro Nohara

TL;DR: The estrogenic activities of soy isoflavones after digestion with enteric bacteria in competition binding assays with hER alpha or hER beta protein, and in a gene expression assay using a yeast system were investigated by the growth of MCF-7 breast cancer cells.

TL;DR: Several flavonoids obtained from barley leaves, soybean and some medicinal plants were tested for their DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity and the structure-activity relationships suggested that not only the numbers of hydroxy group but also the position of Hydroxy group might be important for mediating potent activity.

TL;DR: Two new isoflavone glycosides, the 8-C-apiosyl (1→6) glucosides of daidzein and genistein, were isolated from the roots and the voluble stems of Pueraria lobata (WILLD.) OHWI as mentioned in this paper.

TL;DR: Cytotoxic activities of 20 steroidal glycosides obtained from Solanum genera plants were examined against various cell lines to provide new evidence as to the sugar linkage and the aglycone.

TL;DR: In this paper, the effect on the estrogen-dependent growth of MCF-7 cells, binding ability to human estrogen receptors (hERs) alpha and beta, and effect on hERdependent beta-galactosidase induction, of these isoflavone metabolites were examined.