T
Toshiyuki Shinji
Researcher at Okayama University
Publications - 41
Citations - 1436
Toshiyuki Shinji is an academic researcher from Okayama University. The author has contributed to research in topics: Hepatic stellate cell & Hepatitis C virus. The author has an hindex of 18, co-authored 41 publications receiving 1410 citations.
Papers
More filters
Journal ArticleDOI
Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments.
Norio Koide,Khosaku Sakaguchi,Yayoi Koide,Kenichiro Asano,Mitsuhiko Kawaguchi,Hiroshi Matsushima,Tatsuro Takenami,Toshiyuki Shinji,Masaharu Mori,Takao Tsuji +9 more
TL;DR: Two distinct, mutually exclusive features of primary culture of adult hepatocytes apparently exist; monolayer culture with proliferative activity in an adherent environment and spheroid culture with poor proliferationative activity and high albumin-producing ability in a nonadherent environment.
Journal ArticleDOI
Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans.
Norio Koide,Toshiyuki Shinji,Takayoshi Tanabe,Kenichirou Asano,Mitsuhiko Kawaguchi,Kohsaku Sakaguchi,Yayoi Koide,Masayasu Mori,Takao Tsuji +8 more
TL;DR: The spheroid culture appears to be more suitable than the monolayer in studying differentiated functions of adult hepatocytes, when they were cultured with proteoglycan fraction isolated from rat liver reticulin fibers.
Journal ArticleDOI
Hepatitis C virus genotype distribution in Myanmar: Predominance of genotype 6 and existence of new genotype 6 subtype.
TL;DR: This study was performed to determine the prevalence and distribution of hepatitis C virus genotypes in Myanmar and found that HCV genotypes related to HIV, hepatitis B and hepatitis C are more common than other viruses in Myanmar.
Journal ArticleDOI
Analysis of HCV genotypes from blood donors shows three new HCV type 6 subgroups exist in Myanmar.
Toshiyuki Shinji,Yi Yi Kyaw,Katsunori Gokan,Yasuhito Tanaka,Koji Ochi,Nobuchika Kusano,Takaaki Mizushima,Shinichi Fujioka,Hidenori Shiraha,Aye Aye Lwin,Yasushi Shiratori,Masashi Mizokami,Myo Khin,Masayuki Miyahara,Shigeru Okada,Norio Koide +15 more
TL;DR: Serum samples were obtained from 201 HCV antibody-positive volunteer blood donors in and around the Myanmar city of Yangon and phylogenetic analysis of these type 6 variants revealed that 3 new type 6 subgroups exist in Myanmar, which may be useful for analyzing how and when these subgroups were formed.
Journal Article
Expression of the midkine gene in human hepatocellular carcinomas.
Norio Koide,Hajime Hada,Toshiyuki Shinji,Kozo Ujike,Shoji Hirasaki,Yasuhiro Yumoto,Tadashi Hanafusa,Kenji Kadomatsu,Hisako Muramatsu,Takashi Muramatsu,Takao Tsuji +10 more
TL;DR: The results suggest that MK is expressed in the majority of HCC tissues and rarely in surrounding tissues in chronic liver diseases.