Showing papers in "Hepatology Research in 2007"

TL;DR: The cumulative survival rates of newly registered patients in the 12th to 17th follow‐up surveys conducted between 1992 and 2003 were calculated for each histological type (HCC, ICC, and combined HCC and ICC) and stratified by background factors and treatment.

TL;DR: Population‐based data in the USA indicate low application rate of HCC potentially curative therapy and marked regional differences and Insulin resistance syndrome manifesting as obesity and diabetes is emerging as a risk factor for HCC in theUSA and may operate through the formation of non‐alcoholic fatty liver disease (NAFLD); however, its effect on the current trend remains unclear.

TL;DR: Qualitative issues around screening for hepatocellular carcinoma are reviewed, and selection of the at‐risk group, which screening test to use, and how frequently it should be applied are discussed.

TL;DR: The HBV strains circulating in Africa should be studied and related to clinical outcomes, as it become increasingly evident that heterogeneity in the global distribution of HBV genotypes may be responsible for differences in the clinical outcomes ofHBV infections and the response to antiviral treatment and vaccination.

TL;DR: The aim of the present study was to examine DNA methylation and histone modification changes in hepatocellular carcinomas (HCC) and to evaluate the role of EMT in these changes.

TL;DR: This paper found that long-term high-fat diet (HFD) exposure induces NASH, with excess body weight, hyperinsulinemia and hypercholesteremia in mice.

TL;DR: With advent of reverse‐transcription (RT)/polymerase chain reaction (PCR) for detection of the hepatitis E viral genome, retrospective examinations carried out retrospective examinations showed positive results for RT and PPCR in detecting hepatitis E virus infection.

TL;DR: Even though the condition is uncommon, patients with de novo AIH are now seen in most of the major transplant centres.

TL;DR: Interrelated mechanisms that act to maintain a constant HBF per liver mass are focused on and provide an excellent example of multiple integrative regulation of a major homeostatic organ.

TL;DR: Liver damage due to facultative hepatotoxins is scarcely foreseeable and the prevalence of acute drug‐induced liver injury (DILI) in a specific setting is evaluated, assessing eventual interactions with pre‐existing hepatic illnesses.

TL;DR: Interferon therapy for chronic hepatitis C has reduced the risk factors for development of HCC, especially among patients with sustained response, and the death rates from HCC in each prefecture correlate with the prevalence of anti‐HCV, but not with HBsAg prevalence.

TL;DR: To investigate the roles of epigenetic and genetic alterations of the phosphatase and tensin homologue on chromosome 10 gene (PTEN) in carcinogenesis and the development of hepatocellular carcinomas (HCC).

TL;DR: Evaluated the efficacy of N‐acetylcysteine (NAC) in combination with metformin (MTF) in improving the aminotransferases and histological parameters (steatosis, inflammation, hepatocellular ballooning, and fibrosis) after 12 months of treatment.

TL;DR: A better understanding of the basic mechanisms underlying the gender‐associated differences observed in the progression of chronic liver disease would provide valuable information relative to the search for effective antifibrogenic therapies.

TL;DR: The proposed molecular mechanisms for the action of UDCA, especially in hepatocytes, are summarized, and the putative future clinical usage of this unique drug is discussed.

TL;DR: The role of high viral load was confirmed when another community‐based prospective study of 3644 HBsAg carriers stratified by serum hepatitis B virus (HBV) DNA levels correlated well with the occurrence of HCC, especially in carriers with levels >105 copies/mL.

TL;DR: Patients with high serum hepatitis B virus (HBV) DNA concentrations are at high risk of tumor recurrence after liver resection for HBV‐related hepatocellular carcinoma (HCC).

TL;DR: Compared the diagnostic performance of transient elastography (FibroScan) with that of serum fibrosis markers and stages of hepatic fibrosis by biopsy in 68 patients with chronic hepatitis B virus and in 161 patients with hepatitis C virus infection.

TL;DR: Aim: Non‐alcoholic steatohepatitis (NASH) is one of the representative liver diseases in developed countries and diagnosis is dependent on histological findings from liver biopsy.

TL;DR: The objective was to determine cytokines associated with the progression of acute hepatic injury (AHI) and to comprehensively evaluated the serum levels of 17 cytokines.

TL;DR: This work summarizes the current knowledge on HBV genotypes in countries with low and intermediate HBV carriership from Europe and finds that on treatment with interferon HBV, genotype A, compared to genotype D, shows better virological response and in a large proportion of patients, even development of anti‐HBs.

TL;DR: The clinical significance of hepatitis B virus core‐related antigen (HBcrAg) in predicting the reactivation of hepatitis after halting lamivudine administration was analyzed.

TL;DR: IgG4‐SC may be etiologically different from PSC, and immunopathological processes relating to IgG4 and regulatory T cells may be involved in the pathogenesis of IgG 4‐SC.

TL;DR: The distinct sequence characteristics of subgenotypes A1 may contribute to the 4.5‐fold increased risk of heptocellular carcinoma in HBV carriers infected with genotype A, which is entirely attributable to subgenotype A1.

TL;DR: This study was performed to determine the prevalence and distribution of hepatitis C virus genotypes in Myanmar and found that HCV genotypes related to HIV, hepatitis B and hepatitis C are more common than other viruses in Myanmar.

TL;DR: Patients with hepatitis C who presented in hepatitis clinics in Tehran were investigated for HCV genotypes to study genotypic distribution of HCV in Iran.

TL;DR: Accumulating evidence showed the response rate to antiviral therapy in Chinese patients is higher in genotype B than genotype C patients on interferon treatment, but no difference was observed on nucleoside/nucleotide analog treatment.

TL;DR: The aim of the present study was to clarify the expression of Rab5a in hepatocellular carcinomas (HCC) and to examine its effect on EGF signaling.

TL;DR: Biochemical characterization of long‐term toxic manifestations of anti‐tubercular (anti‐TB) drugs – rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) – individually and in two combinations in Wistar rats.

TL;DR: The present study was performed to clarify the influence of age and gender on the development of Japanese NASH and found it to be similar to other studies of metabolic syndrome.