T
Toyoaki Murohara
Researcher at Nagoya University
Publications - 1320
Citations - 55011
Toyoaki Murohara is an academic researcher from Nagoya University. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 92, co-authored 1190 publications receiving 49931 citations. Previous affiliations of Toyoaki Murohara include Kumamoto University & RMIT University.
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Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
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Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial.
Eriko Tateishi-Yuyama,Hiroaki Matsubara,Toyoaki Murohara,Uichi Ikeda,Satoshi Shintani,Hiroya Masaki,Katsuya Amano,Yuji Kishimoto,Kohji Yoshimoto,Hidetoshi Akashi,Kazuyuki Shimada,Toshiji Iwasaka,Tsutomu Imaizumi +12 more
TL;DR: Autologous implantation of bone marrow-mononuclear cells could be safe and effective for achievement of therapeutic angiogenesis, because of the natural ability of marrow cells to supply endothelial progenitor cells and to secrete various angiogenic factors or cytokines.
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Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Toyoaki Murohara,Takayuki Asahara,Marcy Silver,Christophe Bauters,Haruchika Masuda,Christoph Kalka,Marianne Kearney,Donghui Chen,James F. Symes,Mark C. Fishman,P L Huang,Jeffrey M. Isner +11 more
TL;DR: It is suggested that defective endothelial NO synthesis may limit angiogenesis in patients with endothelial dysfunction related to atherosclerosis, and that oral L-arginine supplementation constitutes a potential therapeutic strategy for accelerating angiogenic in Patients with advanced vascular obstruction.
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Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction
Satoshi Shintani,Toyoaki Murohara,Hisao Ikeda,Takafumi Ueno,Tomoki Honma,Atsushi Katoh,Ken-ichiro Sasaki,Toshifumi Shimada,Yuichi Oike,Tsutomu Imaizumi +9 more
TL;DR: This is the first clinical demonstration showing that lineage-committed EPCs and MNCCD34+, their putative precursors, are mobilized during an acute ischemic event in humans.