T
Toyotaka Yada
Researcher at Kawasaki Medical School
Publications - 57
Citations - 1789
Toyotaka Yada is an academic researcher from Kawasaki Medical School. The author has contributed to research in topics: Microcirculation & Nitric oxide. The author has an hindex of 23, co-authored 57 publications receiving 1725 citations. Previous affiliations of Toyotaka Yada include Kawasaki University of Medical Welfare.
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Journal ArticleDOI
Hydrogen peroxide, an endogenous endothelium-derived hyperpolarizing factor, plays an important role in coronary autoregulation in vivo.
Toyotaka Yada,Hiroaki Shimokawa,Osamu Hiramatsu,Tatsuya Kajita,Fumiyuki Shigeto,Masami Goto,Yasuo Ogasawara,Fumihiko Kajiya +7 more
TL;DR: The results suggest that H2O2 is an endogenous EDHF in vivo and plays an important role in coronary autoregulation in cooperation with NO and adenosine.
Journal ArticleDOI
In vivo observation of subendocardial microvessels of the beating porcine heart using a needle-probe videomicroscope with a CCD camera.
Toyotaka Yada,Osamu Hiramatsu,Akihiro Kimura,Masami Goto,Yasuo Ogasawara,Katsuhiko Tsujioka,Shinji Yamamori,K Ohno,Hidehiro Hosaka,Fumihiko Kajiya +9 more
TL;DR: In 12 open-chest anesthetized pigs, the sheathed needle probe with a doughnut-shaped balloon and a microtube for flushing away the intervening blood was introduced into the left ventricle through an incision in the left atrial appendage via the mitral valve, and the subendocardial microcirculation was observed.
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Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice
Aya Takaki,Keiko Morikawa,Masato Tsutsui,Yoshinori Murayama,Ender Tekes,Hiroto Yamagishi,Junko Ohashi,Toyotaka Yada,Nobuyuki Yanagihara,Hiroaki Shimokawa,Hiroaki Shimokawa +10 more
TL;DR: It is shown that genetic disruption of all three NOS isoforms (neuronal, inducible, and endothelial) abolishes EDHF responses in mice, providing the first evidence that EDHF-mediated responses are dependent on the NOSs system in mouse mesenteric arteries.
Journal Article
Abstract 3629: Crucial Role of Nitric Oxide Synthases System in Endothelium-Dependent Hyperpolarization in Mice
Aya Takaki,Keiko Morikawa,Yoshinori Murayama,Ender Tekes,Hiroto Yamagishi,Junko Ohashi,Masato Tsutsui,Toyotaka Yada,Nobuyuki Yanagihara,Hiroaki Shimokawa +9 more
TL;DR: The authors showed that genetic disruption of all three NOS isoforms (neuronal, inducible, and endothelial) abolishes EDHF responses in mice and provided evidence that EDHF-mediated responses are dependent on the NOSs system in mouse mesenteric arteries.
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Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy.
Minoru Satoh,Sohachi Fujimoto,Sayaka Arakawa,Toyotaka Yada,Tamehachi Namikoshi,Yoshisuke Haruna,Hideyuki Horike,Tamaki Sasaki,Naoki Kashihara +8 more
TL;DR: ARB improved the NOS uncoupling in diabetic nephropathy by increasing BH4 bioavailability and reversed the decreased GTPCH1 and decreased dimeric form of eNOS and glomerular NO production by increased BH 4 bioavailability.