T
Tracy Rourke
Researcher at University of California, Davis
Publications - 19
Citations - 1914
Tracy Rourke is an academic researcher from University of California, Davis. The author has contributed to research in topics: Simian immunodeficiency virus & Immune system. The author has an hindex of 17, co-authored 19 publications receiving 1845 citations. Previous affiliations of Tracy Rourke include California National Primate Research Center.
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Journal ArticleDOI
Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells
Qingsheng Li,Lijie Duan,Jacob D. Estes,Zhong-Min Ma,Tracy Rourke,Yichuan Wang,Cavan S. Reilly,John V. Carlis,Christopher J. Miller,Christopher J. Miller,Ashley T. Haase +10 more
TL;DR: It is shown that peak virus production in gut tissues of SIV-infected rhesus macaques coincides with peak numbers of infected memory CD4+ T cells, underscoring the importance of developing countermeasures to SIV that are effective before infection of GALT.
Journal ArticleDOI
The strength of B cell immunity in female rhesus macaques is controlled by CD8+ T cells under the influence of ovarian steroid hormones
Fabien X.-S. Lü,Kristina Abel,Zhong-Min Ma,Tracy Rourke,Ding Lu,Judith Torten,Michael B. McChesney,Christopher J. Miller +7 more
TL;DR: The changes in B cell Ig secretory activity that the authors document in the tissues of female rhesus macaques during the menstrual cycle is due apparently to the action of ovarian steroid hormones on CD8+ T cells, which control B cellsecretory activity in both mucosal and systemic immune compartments.
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Simian-Human Immunodeficiency Virus SHIV89.6-Induced Protection against Intravaginal Challenge with Pathogenic SIVmac239 Is Independent of the Route of Immunization and Is Associated with a Combination of Cytotoxic T-Lymphocyte and Alpha Interferon Responses
Kristina Abel,Lara Compton,Lara Compton,Tracy Rourke,Tracy Rourke,David C. Montefiori,Ding Lu,Ding Lu,Kristina Rothaeusler,Linda Fritts,Linda Fritts,Kristen Bost,Christopher J. Miller,Christopher J. Miller +13 more
TL;DR: Attenuated primate lentivirus vaccines provide the most consistent protection against challenge with pathogenic simian immunodeficiency virus (SIV) and provide an excellent model to examine the influence of the route of immunization on challenge outcome and to study vaccine-induced protective anti-SIV immune responses.
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Immunization of Newborn Rhesus Macaques with Simian Immunodeficiency Virus (SIV) Vaccines Prolongs Survival after Oral Challenge with Virulent SIVmac251
Koen K. A. Van Rompay,Jennifer L. Greenier,Kelly Stefano Cole,Patricia L. Earl,Bernard Moss,Jonathan D. Steckbeck,Bapi Pahar,Tracy Rourke,Ronald C. Montelaro,Don R. Canfield,Ross P. Tarara,Christopher J. Miller,Christopher J. Miller,Michael B. McChesney,Marta L. Marthas,Marta L. Marthas +15 more
TL;DR: Although the tested vaccines delayed the onset of AIDS, further studies are warranted to determine whether a vaccine that elicits stronger early immune responses at the time of virus exposure may be able to prevent viral infection or AIDS in infants.
Journal ArticleDOI
Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques.
Timothy D. Carroll,Timothy D. Carroll,Ming Lo,Ming Lo,Marion C. Lanteri,Joseph Dutra,Joseph Dutra,Katie Zarbock,Paola P. Silveira,Tracy Rourke,Tracy Rourke,Zhong-Min Ma,Zhong-Min Ma,Linda Fritts,Linda Fritts,Shelby L. O’Connor,Michael P. Busch,Christopher J. Miller,Christopher J. Miller +18 more
TL;DR: The results support the conclusion that ZIKV preferentially replicates in the FRT after vaginal transmission, but not after SQ transmission, and raise the possibility that there is enhanced fetal infection and pathology after vaginal ZikV transmission compared to a mosquito transmitted ZikaV.