Z
Zhong-Min Ma
Researcher at California National Primate Research Center
Publications - 59
Citations - 4038
Zhong-Min Ma is an academic researcher from California National Primate Research Center. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 27, co-authored 53 publications receiving 3764 citations. Previous affiliations of Zhong-Min Ma include University of California, Davis & École Normale Supérieure.
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Journal ArticleDOI
Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells
Qingsheng Li,Lijie Duan,Jacob D. Estes,Zhong-Min Ma,Tracy Rourke,Yichuan Wang,Cavan S. Reilly,John V. Carlis,Christopher J. Miller,Christopher J. Miller,Ashley T. Haase +10 more
TL;DR: It is shown that peak virus production in gut tissues of SIV-infected rhesus macaques coincides with peak numbers of infected memory CD4+ T cells, underscoring the importance of developing countermeasures to SIV that are effective before infection of GALT.
Journal ArticleDOI
Propagation and Dissemination of Infection after Vaginal Transmission of Simian Immunodeficiency Virus
Christopher J. Miller,Qingsheng Li,Kristina Abel,Eun Young Kim,Zhong-Min Ma,Stephen W. Wietgrefe,Lisa La Franco-Scheuch,Lara Compton,Lijie Duan,Marta Dykhuizen Shore,Mary Zupancic,Marc Busch,John V. Carlis,Steven Wolinksy,Ashley T. Haase +14 more
TL;DR: It is shown that the mucosal barrier greatly limits the infection of cervicovaginal tissues, and thus the initial founder populations of infected cells are small, and that continuous seeding from an expanding source of production at the portal of entry is likely critical for the later establishment of a productive infection throughout the systemic LTs.
Journal ArticleDOI
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.
David Favre,Sharon Lederer,Bittoo Kanwar,Zhong-Min Ma,Sean Proll,Zeljka Kasakow,Jeff E. Mold,Louise A. Swainson,Jason D. Barbour,Carole R. Baskin,Robert E. Palermo,Ivona Pandrea,Christopher J. Miller,Michael G. Katze,Joseph M. McCune +14 more
TL;DR: Comparing acute pathogenic SIV infection in pigtailed macaques to non-pathogenic infection in African green monkeys indicates that loss of the Th17 to Treg balance is related to SIV disease progression.
Journal ArticleDOI
Adjuvant-dependent Innate and Adaptive Immune Signatures of Risk of SIVmac251 Acquisition
Monica Vaccari,Shari N. Gordon,Slim Fourati,Luca Schifanella,Luca Schifanella,Namal P.M. Liyanage,Mark J. Cameron,Brandon F. Keele,Xiaoying Shen,Georgia D. Tomaras,Erik Billings,Mangala Rao,Amy W. Chung,Karen G Dowell,Chris Bailey-Kellogg,Eric P. Brown,Margaret E. Ackerman,Diego A. Vargas-Inchaustegui,Stephen Whitney,Melvin N. Doster,Nicolo Binello,Poonam Pegu,David C. Montefiori,Kathryn E. Foulds,David S Quinn,Mitzi M. Donaldson,Frank Liang,Karin Loré,Mario Roederer,Richard A. Koup,Adrian B. McDermott,Zhong-Min Ma,Christopher J. Miller,Tran B. Phan,Donald N. Forthal,Matthew Blackburn,Francesca Caccuri,Massimiliano Bissa,Guido Ferrari,Vaniambadi S. Kalyanaraman,Maria Grazia Ferrari,DeVon Thompson,Marjorie Robert-Guroff,Silvia Ratto-Kim,Jerome H. Kim,Nelson L. Michael,Sanjay Phogat,Susan W. Barnett,Jim Tartaglia,David Venzon,Donald Stablein,Galit Alter,Rafick-Pierre Sekaly,Genoveffa Franchini +53 more
TL;DR: It is found here that an ALVAC–simian immunodeficiency virus (SIV) and gp120 alum (ALVAC-SIV + gp120) equivalent vaccine, but not an ALvAC–SIV - gp120 MF59 vaccine, was efficacious in delaying the onset of SIVmac251 in rhesus macaques, despite the higher immunogenicity of the latter adjuvant.
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CD8+ T-Lymphocyte Response to Major Immunodominant Epitopes after Vaginal Exposure to Simian Immunodeficiency Virus: Too Late and Too Little
Matthew R. Reynolds,Eva G. Rakasz,Pamela J. Skinner,Cara White,Kristina Abel,Zhong-Min Ma,Lara Compton,Gnankang Napoé,Nancy A. Wilson,Christopher J. Miller,Ashley T. Haase,David I. Watkins +11 more
TL;DR: The robust response in female reproductive tissues may be an encouraging sign that vaccines that rapidly induce high-frequency CD8+ T-lymphocyte responses might be able to prevent acquisition of HIV-1 infection by the most common route of transmission.