T
Trupti N. Brahmbhatt
Researcher at Naval Medical Research Center
Publications - 5
Citations - 282
Trupti N. Brahmbhatt is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Bacillus anthracis & Exosporium. The author has an hindex of 5, co-authored 5 publications receiving 265 citations. Previous affiliations of Trupti N. Brahmbhatt include Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Bacillus anthracis exosporium protein BclA affects spore germination, interaction with extracellular matrix proteins, and hydrophobicity.
Trupti N. Brahmbhatt,Brian K. Janes,E. Scott Stibitz,Stephen C. Darnell,Patrick Sanz,Susan B. Rasmussen,Alison D. O'Brien +6 more
TL;DR: It is suggested that BclA acts as a shield to not only reduce the ease with which spores germinate but also change the surface properties of the spore, which, in turn, may impede the interaction with host matrix substances.
Journal ArticleDOI
Recombinant Exosporium Protein BclA of Bacillus anthracis Is Effective as a Booster for Mice Primed with Suboptimal Amounts of Protective Antigen
Trupti N. Brahmbhatt,Stephen C. Darnell,Humberto M. Carvalho,Patrick Sanz,Tae J. Kang,Robert L. Bull,Susan B. Rasmussen,Alan S. Cross,Alison D. O'Brien +8 more
TL;DR: The concept of rBclA as being a safe and effective boost for a PA-primed individual against anthrax is supported and it is suggested that such rBClA-enhanced protection occurs by the induction of spore-opsonizing and germination-inhibiting antibodies.
Journal ArticleDOI
Arbovirus detection in insect vectors by rapid, high-throughput pyrosequencing.
Kimberly A. Bishop-Lilly,Michael J. Turell,Kristin M Willner,Amy Butani,Nichole Nolan,Shannon M. Lentz,Arya Akmal,Al Mateczun,Trupti N. Brahmbhatt,Shanmuga Sozhamannan,Chris A. Whitehouse,Timothy D. Read +11 more
TL;DR: Dengue virus type 1 RNA was sufficiently concentrated in the mosquito that its detection was feasible using current high-throughput sequencing instrumentation, and some of the components of the mosquito microflora were identified on the basis of the sequence of expressed RNA.
Journal ArticleDOI
Bacillus cereus G9241 Makes Anthrax Toxin and Capsule like Highly Virulent B. anthracis Ames but Behaves like Attenuated Toxigenic Nonencapsulated B. anthracis Sterne in Rabbits and Mice
Melissa K. Wilson,James M. Vergis,Farhang Alem,John R. Palmer,Andrea M. Keane-Myers,Trupti N. Brahmbhatt,Christy L. Ventura,Alison D. O'Brien +7 more
TL;DR: It is concluded that the presence of the toxin- and capsule-encoding plasmids pBCXO1 and pBC218 in B. cereus G9241 alone is insufficient to render the strain as virulent as B. anthracis Sterne.
Journal ArticleDOI
Rapid Identification of Genetic Modifications in Bacillus anthracis Using Whole Genome Draft Sequences Generated by 454 Pyrosequencing
Peter E. Chen,Kristin M Willner,Amy Butani,Shakia Dorsey,Matroner George,Andrew C. Stewart,Shannon M. Lentz,Christopher Cook,Arya Akmal,Lance B. Price,Paul Keim,Paul Keim,Alfred J. Mateczun,Trupti N. Brahmbhatt,Kimberly A. Bishop-Lilly,Michael E. Zwick,Timothy D. Read,Shanmuga Sozhamannan +17 more
TL;DR: The Roche 454-based pyrosequencing can generate whole genome draft sequences of deep and broad enough coverage of a bacterial genome in less than 24 hours, and unbiased identification of known as well as heretofore-unreported genetic modifications that include indels and single nucleotide polymorphisms conferring antibiotic and phage resistances is feasible within the next 12 hours.