T
Tsukasa Sugo
Researcher at Takeda Pharmaceutical Company
Publications - 45
Citations - 1757
Tsukasa Sugo is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Receptor & Ligand (biochemistry). The author has an hindex of 16, co-authored 45 publications receiving 1594 citations. Previous affiliations of Tsukasa Sugo include University of Tokyo & Alnylam Pharmaceuticals.
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Journal ArticleDOI
Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14).
Masaaki Mori,Tsukasa Sugo,Michiko Abe,Yukio Shimomura,Mika Kurihara,Chieko Kitada,Kuniko Kikuchi,Yasushi Shintani,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +11 more
TL;DR: Two molecular species of urotensin II (UII) were isolated from porcine spinal cords and identified as the endogenous ligands of a G-protein-coupled orphan receptor, SENR (sensory epithelium neuropeptide-like receptor), which is identical to GPR14.
Journal ArticleDOI
Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells
Genc Basha,Tatiana Novobrantseva,Nicole L. Rosin,Yuen Yi C. Tam,Ismail M. Hafez,Matthew K Wong,Tsukasa Sugo,Vera M. Ruda,June Qin,Boris Klebanov,Marco A. Ciufolini,Akin Akinc,Ying K. Tam,Michael J. Hope,Pieter R. Cullis +14 more
TL;DR: In vivo results showed that LNP siRNA systems containing DLinKC2-DMA are effective agents for silencing GAPDH in APCs in the spleen and peritoneal cavity following systemic administration.
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Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor.
Yukio Shimomura,Masaaki Mori,Tsukasa Sugo,Yoshihiro Ishibashi,Michiko Abe,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Yasuhiro Sumino,Masahiko Fujino +9 more
TL;DR: Melanin-concentrating hormone, which is an orexigenic peptide, was isolated and identified as the endogenous ligand of the SLC-1 receptor and demonstrated a dose-dependent inhibitory effect on cAMP accumulation in forskolin-stimulated rat and human S LC-1-expressing CHO cells.
Journal ArticleDOI
Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.
Yukio Shimomura,Mioko Harada,Mika Goto,Tsukasa Sugo,Yoshio Matsumoto,Michiko Abe,Takuya Watanabe,Taiji Asami,Chieko Kitada,Masaaki Mori,Haruo Onda,Masahiko Fujino +11 more
TL;DR: Findings indicate that neuropeptide W is the endogenous ligand for both GPR7 and GPR8 and acts as a mediator of the central control of feeding and the neuroendocrine system.
Journal ArticleDOI
Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain☆☆☆
Tsukasa Sugo,Yuko Murakami,Yukio Shimomura,Mioko Harada,Michiko Abe,Yoshihiro Ishibashi,Chieko Kitada,Nobuyuki Miyajima,Nobuhiro Suzuki,Masaaki Mori,Masahiko Fujino +10 more
TL;DR: URP was found to bind and activate the human or rat UII receptors (GPR14) and showed a hypotensive effect when administered to anesthetized rats, suggesting that URP is the endogenous and functional ligand for UII receptor in the rat and mouse, and possibly in the human.