Yukio Shimomura

TL;DR: Results clearly indicate that T-226296 is a novel, orally active and selective MCH receptor antagonist that will be promising for further exploring the physiology and pathophysiology of MCH-SLC-1 signaling.

TL;DR: Two molecular species of urotensin II (UII) were isolated from porcine spinal cords and identified as the endogenous ligands of a G-protein-coupled orphan receptor, SENR (sensory epithelium neuropeptide-like receptor), which is identical to GPR14.

TL;DR: Melanin-concentrating hormone, which is an orexigenic peptide, was isolated and identified as the endogenous ligand of the SLC-1 receptor and demonstrated a dose-dependent inhibitory effect on cAMP accumulation in forskolin-stimulated rat and human S LC-1-expressing CHO cells.

TL;DR: Findings indicate that neuropeptide W is the endogenous ligand for both GPR7 and GPR8 and acts as a mediator of the central control of feeding and the neuroendocrine system.

TL;DR: URP was found to bind and activate the human or rat UII receptors (GPR14) and showed a hypotensive effect when administered to anesthetized rats, suggesting that URP is the endogenous and functional ligand for UII receptor in the rat and mouse, and possibly in the human.