Tsung-I Tsai

TL;DR: It was found that the biantennary N-glycan structure with two terminal alpha-2,6-linked sialic acids is a common and optimized structure for the enhancement of antibody-dependent cell-mediated cytotoxicity, complement-dependent cytot toxicity, and antiinflammatory activities.

TL;DR: The development of chemoenzymatic methods for the large-scale synthesis of cancer-associated antigens globopentaose, fucosyl-Gb5, and SSEA4 by using overexpressed glycosyltransferases coupled with effective regeneration of sugar nucleotides, including UDP- Gal, UDP-GalNAc, GDP-Fuc, and CMP-Neu5Ac are reported.

TL;DR: A glycan microarray on an aluminium-oxide-coated glass slide containing a diverse set of glycans, including homo- and mixed N-glycans that were prepared by modular chemo-enzymatic methods to detect the presence of hetero-glycan binding behaviours could speed up the development of HIV-1 vaccines targeting cell surface glycans.

TL;DR: It is shown that the mice immunized with a l-fucose (Fuc)-enriched Reishi polysaccharide fraction (designated as FMS) induce antibodies against murine Lewis lung carcinoma cells, with increased antibody-mediated cytotoxicity and reduced production of tumor-associated inflammatory mediators (in particular, monocyte chemoattractant protein-1).

TL;DR: A unified convergent strategy for the rapid production of bi-, tri-, and tetra-antennary complex type N-glycans with and without terminal N-acetylneuraminic acid residues connected via the α-2,6 or α- 2,3 linkages is reported.