T
Tsutomu Takahashi
Researcher at Women's College, Kolkata
Publications - 56
Citations - 1425
Tsutomu Takahashi is an academic researcher from Women's College, Kolkata. The author has contributed to research in topics: Tyrosine hydroxylase & Dopaminergic. The author has an hindex of 20, co-authored 42 publications receiving 1378 citations.
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Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies
Makoto Naoi,Wakako Maruyama,Philippe Dostert,Yoshio Hashizume,Daiichiro Nakahara,Tsutomu Takahashi,Miyuki Ota +6 more
TL;DR: The results demonstrate the selective cytotoxicity of NM(R)Sal to the dopamine neurons in the substantia nigra, and the possible involvement of this 6,7-dihydroxy-isoquinoline in the pathogenesis of Parkinson's disease is discussed.
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A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion.
TL;DR: Enzymatic formation of NMTIQ indicates that in human brain this compound may be an intermediate of biosynthesis of a potent neurotoxin of dopamine metabolism, N-methylisoquinolinium ion, from naturally-occurring TIQ.
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Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system.
TL;DR: The results suggest that the selective uptake by dopamine transporter may account for the specific neurotoxicity of (R)-1,2-DiMeDHTIQ to dopamine neurons.
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N-methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: in vivo microdialysis study.
Wakako Maruyama,Daiichiro Nakahara,Miyuki Ota,Tsutomu Takahashi,Akira Takahashi,Toshiharu Nagatsu,Makoto Naoi +6 more
TL;DR: N‐Methylation of (R)‐1‐methyl‐6,7‐dihydroxy‐1,2,3,4‐tetrahydroisoquinoline [(R]‐salsolinol] derived from dopamine was proved by in vivo microdialysis study in the rat brain to be an essential step for these alkaloids to increase their toxicity.
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An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells.
Wakako Maruyama,Makoto Naoi,Toshio Kasamatsu,Yoshio Hashizume,Tsutomu Takahashi,Kohfuku Kohda,Philippe Dostert +6 more
TL;DR: Apoptosis induced by neurotoxins may be a mechanism underlying the cell death of dopamine neurons in the substantia nigra of Parkinson's disease.