T
Tsuyoshi Waku
Researcher at Doshisha University
Publications - 35
Citations - 1126
Tsuyoshi Waku is an academic researcher from Doshisha University. The author has contributed to research in topics: Proteasome & Transcription factor. The author has an hindex of 16, co-authored 32 publications receiving 898 citations. Previous affiliations of Tsuyoshi Waku include University of Tokyo & University of Tsukuba.
Papers
More filters
Journal ArticleDOI
Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids.
Tsuyoshi Waku,Takuma Shiraki,Takuji Oyama,Yoshito Fujimoto,Kanako Maebara,Narutoshi Kamiya,Hisato Jingami,Kosuke Morikawa +7 more
TL;DR: The crystallographic study of LBD complexed with nitro-233 demonstrated that the expected covalent bond is indeed formed between this newly identified agonist and the cysteine, and suggested that the loop conformation may be responsible for the modulation of PPARgamma activity.
Journal ArticleDOI
The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites.
TL;DR: It is reported that serotonin metabolites act as endogenous agonists for PPARγ to regulate macrophage function and adipogenesis by directly binding to helix H12.
Journal ArticleDOI
A nonclassical vitamin D receptor pathway suppresses renal fibrosis
Ichiaki Ito,Tsuyoshi Waku,Masato Aoki,Rumi Abe,Yu Nagai,Tatsuya Watanabe,Yuka Nakajima,Ichiro Ohkido,Keitaro Yokoyama,Hiroyuki Miyachi,Toshiyuki Shimizu,Akiko Murayama,Hiroyuki Kishimoto,Kazuo Nagasawa,Junn Yanagisawa +14 more
TL;DR: This study found that 1,25-dihydroxyvitamin D3-bound [1,25(OH)2D3- bound] vitamin D receptor (VDR) specifically inhibits TGF-β-SMAD signal transduction through direct interaction with SMAD3.
Journal ArticleDOI
Global analysis of DNA methylation in early-stage liver fibrosis
TL;DR: The genome-wide analysis of DNA methylation status revealed that DNA hypomethylation of the genes responsible for fibrosis may precede the onset of liver fibrosis and subsequent progression to HCC, and suggested that Spp1 expression is increased in HCC.
Journal ArticleDOI
NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.
Tsuyoshi Waku,Yuka Nakajima,Wataru Yokoyama,Naoto Nomura,Koichiro Kako,Akira Kobayashi,Toshiyuki Shimizu,Akiyoshi Fukamizu +7 more
TL;DR: It is demonstrated that a nucleolar factor, nucleomethylin (NML), is required for the N1-methyladenosine (m1A) modification in 28S rRNAs of human and mouse cells, which links ribosomal subunit formation to p53-dependent inhibition of cell proliferation in mammalian cells.