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Akira Kobayashi
Researcher at Doshisha University
Publications - 95
Citations - 15746
Akira Kobayashi is an academic researcher from Doshisha University. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 39, co-authored 92 publications receiving 14135 citations. Previous affiliations of Akira Kobayashi include University of Tsukuba & Kansai Medical University.
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Journal ArticleDOI
Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
Masaaki Komatsu,Satoshi Waguri,Masato Koike,Yu-shin Sou,Yu-shin Sou,Takashi Ueno,Taichi Hara,Noboru Mizushima,Junichi Iwata,Junichi Iwata,Junji Ezaki,Shigeo Murata,Jun Hamazaki,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Toru Yanagawa,Junya Uwayama,Eiji Warabi,Hiroshi Yoshida,Tetsuro Ishii,Akira Kobayashi,Masayuki Yamamoto,Zhenyu Yue,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka +26 more
TL;DR: The findings highlight the unexpected role of homeostatic level of p62, which is regulated by autophagy, in controlling intracellular inclusion body formation, and indicate that the pathologic process associated with autophagic deficiency is cell-type specific.
Journal ArticleDOI
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Masaaki Komatsu,Hirofumi Kurokawa,Satoshi Waguri,Keiko Taguchi,Akira Kobayashi,Yoshinobu Ichimura,Yoshinobu Ichimura,Yu-shin Sou,Yu-shin Sou,Izumi Ueno,Ayako Sakamoto,Kit I. Tong,Mihee Kim,Yasumasa Nishito,Shun-ichiro Iemura,Tohru Natsume,Takashi Ueno,Eiki Kominami,Hozumi Motohashi,Keiji Tanaka,Masayuki Yamamoto +20 more
TL;DR: The findings indicate that the pathological process associated with p62 accumulation results in hyperactivation of Nrf2 and delineates unexpected roles of selective autophagy in controlling the transcription of cellular defence enzyme genes.
Journal ArticleDOI
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Akira Kobayashi,Moon Il Kang,Hiromi Okawa,Makiko Ohtsuji,Yukari Zenke,Tomoki Chiba,Kazuhiko Igarashi,Masayuki Yamamoto +7 more
TL;DR: It is found that both the BTB and intervening-region (IVR) domains are crucial for Nrf2 degradation, implying that these two domains act to recruit ubiquitin-proteasome factors.
Journal ArticleDOI
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Nobunao Wakabayashi,Albena T. Dinkova-Kostova,W. David Holtzclaw,Moon Il Kang,Akira Kobayashi,Masayuki Yamamoto,Thomas W. Kensler,Paul Talalay +7 more
TL;DR: Evidence for formation of intermolecular disulfide bridges was obtained by 2D PAGE of extracts of cells treated with inducers, and by the demonstration that whereas C273A and C288A mutants of Keap1 alone could not repress Nrf2 activation of the ARE-luciferase reporter, an equal mixture of these mutant constructs restored repressor activity.
Journal ArticleDOI
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.
Akira Kobayashi,Moon Il Kang,Yoriko Watai,Kit I. Tong,Takahiro Shibata,Koji Uchida,Masayuki Yamamoto +6 more
TL;DR: The contention that Nrf2 protein synthesized de novo after exposure to stress accumulates in the nucleus by bypassing the Keap1 gate supports the contention that the sensory mechanism of oxidative and electrophilic stresses is closely linked to the degradation mechanism of NRF2.