T
Tuff Witarama
Researcher at Semel Institute for Neuroscience and Human Behavior
Publications - 9
Citations - 751
Tuff Witarama is an academic researcher from Semel Institute for Neuroscience and Human Behavior. The author has contributed to research in topics: Sleep disorder & Proinflammatory cytokine. The author has an hindex of 9, co-authored 9 publications receiving 537 citations. Previous affiliations of Tuff Witarama include University of California, Los Angeles.
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Journal ArticleDOI
Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial.
Michael R. Irwin,Richard G. Olmstead,Carmen Carrillo,Nina Sadeghi,Elizabeth C. Breen,Tuff Witarama,Megumi Yokomizo,Helen Lavretsky,Judith E. Carroll,Sarosh J. Motivala,Richard R. Bootzin,Perry M. Nicassio +11 more
TL;DR: Treatment of late-life insomnia is better achieved and sustained by cognitive behavioral therapies, and reduces a marker of inflammatory risk, which has implications for cardiovascular morbidity and diabetes observed with sleep disturbance in epidemiologic surveys.
Journal ArticleDOI
Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late Life Insomnia: A Randomized Controlled Trial
Michael R. Irwin,Michael R. Irwin,Richard G. Olmstead,Elizabeth C. Breen,Elizabeth C. Breen,Tuff Witarama,Carmen Carrillo,Nina Sadeghi,Jesusa M.G. Arevalo,Jeffrey Ma,Jeffrey Ma,Perry M. Nicassio,Perry M. Nicassio,Richard R. Bootzin,Steve W. Cole,Steve W. Cole +15 more
TL;DR: Among older adults with insomnia, CBT-I reduced systemic inflammation, TCC reduced cellular inflammatory responses, and both treatments reduced expression of genes encoding proinflammatory mediators.
Journal ArticleDOI
Tai Chi, Cellular Inflammation, and Transcriptome Dynamics in Breast Cancer Survivors With Insomnia: A Randomized Controlled Trial
Michael R. Irwin,Richard G. Olmstead,Elizabeth C. Breen,Tuff Witarama,Carmen Carrillo,Nina Sadeghi,Jesusa M.G. Arevalo,Jeffrey Ma,Perry M. Nicassio,Patricia A. Ganz,Julienne E. Bower,Steve W. Cole +11 more
TL;DR: Among breast cancer survivors with insomnia, 3 months of TCC reduced cellular inflammatory responses, and reduced expression of genes encoding proinflammatory mediators.
Journal ArticleDOI
Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans
TL;DR: Test the effects of experimental sleep loss on spontaneous cellular inflammation and activation of signal transducer and activator of transcription (STAT) family proteins, which together promote an inflammatory microenvironment.
Journal ArticleDOI
Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans.
Judith E. Carroll,Steven W. Cole,Teresa E. Seeman,Elizabeth C. Breen,Tuff Witarama,Jesusa M.G. Arevalo,Jeffrey Ma,Michael R. Irwin +7 more
TL;DR: Findings causally link sleep deprivation to the molecular processes associated with biological aging in older adult humans.