Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds

Small-molecule H-bond donors in asymmetric catalysis.

2.5. Stabilization of IL Emulsions by Nanoparticles 2623 3. Hydrogenations in ILs 2623 3.1. Hydrogenation on IL-Stabilized Nanoparticles 2623 3.1.1. Hydrogenation of 1,3-Butadiene 2623 3.1.2. Hydrogenation of Alkenes and Arenes 2624 3.1.3. Hydrogenation of Ketones 2624 3.2. Homogeneous Catalytic Hydrogenation in ILs 2624 3.3. Hydrogenation of Functionalized ILs 2625 3.3.1. Selective Hydrogenation of Polymers 2625 3.4. Asymmetric Hydrogenations 2626 3.4.1. Enantioselective Hydrogenation 2626 3.5. Role of the ILs Purity in Hydrogenation Reactions 2628

Catalysis in ionic liquids

Stronger Brønsted acids

The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.

Cascade reactions in total synthesis.

Starting from aryl propiolates of Baylis—Hillman alcohols an important class of 1,5-bisarylpent-1-en-4-ynes is prepared.

A Highly Regio- and Stereoselective Pd-Catalyzed Tandem Allylic Rearrangement/Intramolecular Decarboxylative Coupling of Aryl Propiolates Derived from Baylis—Hillman Adducts.

A novel reaction involving tandem construction of C–N and C–C bonds via the simultaneous Ritter and Houben–Hoesch reactions on Baylis–Hillman adducts leading to a convenient, one-pot synthesis of 2-benzazepine derivatives is described. A facile stereoselective transformation of the Baylis–Hillman adducts into (E)- and (Z)-allyl amides is also presented.

A Novel, Tandem Construction of C—N and C—C Bonds: Facile and One-Pot Transformation of the Baylis—Hillman Adducts into 2-Benzazepines.

The method is only applicable to 3-alkoxy-substituted benzyl aziridines since benzyl aziridines lacking the 3-alkoxy group yield no tetrahydroquinolines, but amino alcohols instead.

Tummanapalli Satyanarayana

Papers

A Highly Regio- and Stereoselective Pd-Catalyzed Tandem Allylic Rearrangement/Intramolecular Decarboxylative Coupling of Aryl Propiolates Derived from Baylis—Hillman Adducts.

A Novel, Tandem Construction of C—N and C—C Bonds: Facile and One-Pot Transformation of the Baylis—Hillman Adducts into 2-Benzazepines.

Scandium(III) Triflate Mediated Intramolecular Ring Expansion of Aziridines: A Direct Access to 4‐Aryltetrahydroisoquinolines.