Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds

Small-molecule H-bond donors in asymmetric catalysis.

2.5. Stabilization of IL Emulsions by Nanoparticles 2623 3. Hydrogenations in ILs 2623 3.1. Hydrogenation on IL-Stabilized Nanoparticles 2623 3.1.1. Hydrogenation of 1,3-Butadiene 2623 3.1.2. Hydrogenation of Alkenes and Arenes 2624 3.1.3. Hydrogenation of Ketones 2624 3.2. Homogeneous Catalytic Hydrogenation in ILs 2624 3.3. Hydrogenation of Functionalized ILs 2625 3.3.1. Selective Hydrogenation of Polymers 2625 3.4. Asymmetric Hydrogenations 2626 3.4.1. Enantioselective Hydrogenation 2626 3.5. Role of the ILs Purity in Hydrogenation Reactions 2628

Catalysis in ionic liquids

Stronger Brønsted acids

The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.

Cascade reactions in total synthesis.

Amplification of the enantiomeric excess of a compound in kinetic resolution by a racemic reagent

Asymmetric amplification in catalysis by trans-1,2-diaminocyclohexane bistriflamide.

Scandium(III) triflate mediated intramolecular ring expansion of aziridines: a direct access to 4-aryltetrahydroisoquinolines

The reaction of a racemic reagent on a mixture of enantiomers with small ee (ee = enantiomeric excess) has been studied for amine acylation. A substantial asymmetric amplification could be realized, for example, from 67 to > 95.5 ee. The combination of asymmetric amplifications is subsequently discussed. Two sequential asymmetric amplifications, one using a racemic reagent and another using a positive nonlinear effect allowed us to start from 1.5% ee and end with a large amount of a product of 97 % ee.

Asymmetric amplification by kinetic resolution using a racemic reagent: example in amine acetylation.

A highly regio- and stereoselective Pd-catalyzed tandem allylic rearrangement/intramolecular decarboxylative coupling of aryl propiolates derived from Baylis–Hillman adducts

Tummanapalli Satyanarayana

Papers

Amplification of the enantiomeric excess of a compound in kinetic resolution by a racemic reagent

Asymmetric amplification in catalysis by trans-1,2-diaminocyclohexane bistriflamide.

Scandium(III) triflate mediated intramolecular ring expansion of aziridines: a direct access to 4-aryltetrahydroisoquinolines

Asymmetric amplification by kinetic resolution using a racemic reagent: example in amine acetylation.

A highly regio- and stereoselective Pd-catalyzed tandem allylic rearrangement/intramolecular decarboxylative coupling of aryl propiolates derived from Baylis–Hillman adducts