Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds

Small-molecule H-bond donors in asymmetric catalysis.

2.5. Stabilization of IL Emulsions by Nanoparticles 2623 3. Hydrogenations in ILs 2623 3.1. Hydrogenation on IL-Stabilized Nanoparticles 2623 3.1.1. Hydrogenation of 1,3-Butadiene 2623 3.1.2. Hydrogenation of Alkenes and Arenes 2624 3.1.3. Hydrogenation of Ketones 2624 3.2. Homogeneous Catalytic Hydrogenation in ILs 2624 3.3. Hydrogenation of Functionalized ILs 2625 3.3.1. Selective Hydrogenation of Polymers 2625 3.4. Asymmetric Hydrogenations 2626 3.4.1. Enantioselective Hydrogenation 2626 3.5. Role of the ILs Purity in Hydrogenation Reactions 2628

Catalysis in ionic liquids

Stronger Brønsted acids

The design and implementation of cascade reactions is a challenging facet of organic chemistry, yet one that can impart striking novelty, elegance, and efficiency to synthetic strategies. The application of cascade reactions to natural products synthesis represents a particularly demanding task, but the results can be both stunning and instructive. This Review highlights selected examples of cascade reactions in total synthesis, with particular emphasis on recent applications therein. The examples discussed herein illustrate the power of these processes in the construction of complex molecules and underscore their future potential in chemical synthesis.

Cascade reactions in total synthesis.

A facile, simple and one-pot conversion of methyl 3-aryl-3-hydroxy-2-methylenepropanoates into methyl (2E)-3-aryl-2-hydroxymethylprop-2-enoates via the sequential treatment with acetic anhydride/trimethylsilyl trifluoromethanesulfonate (TMSOTf) and potassium carbonate/methanol is described.

The Baylis—Hillman Reaction: One‐Pot Stereoselective Synthesis of Methyl (2E)‐3‐Aryl‐2‐hydroxymethylprop‐2‐enoates.

Recent Advances in the Baylis—Hillman Reaction and Applications

The Baylis—Hillman Bromides as Versatile Synthons: A Facile One-Pot Synthesis of Indolizine and Benzofused Indolizine Frameworks.

A Novel and Facile Synthesis of Functionalized [4.4.3] and [4.4.4]Propellano-bislactones (V) Using Acetates (II) of the Baylis—Hillman Adducts.

A facile, one-pot convenient transformation of the acetates of Baylis–Hillman adducts into fused pyrimidones, i.e. 3-substituted-1,5-diazabicyclo(4.4.0)deca-2,5,7,9-tetraen-4-ones via reaction with 2-aminopyridine in environmentally friendly aqueous media is described.

Tummanapalli Satyanarayana

Papers

The Baylis—Hillman Reaction: One‐Pot Stereoselective Synthesis of Methyl (2E)‐3‐Aryl‐2‐hydroxymethylprop‐2‐enoates.

Recent Advances in the Baylis—Hillman Reaction and Applications

The Baylis—Hillman Bromides as Versatile Synthons: A Facile One-Pot Synthesis of Indolizine and Benzofused Indolizine Frameworks.

A Novel and Facile Synthesis of Functionalized [4.4.3] and [4.4.4]Propellano-bislactones (V) Using Acetates (II) of the Baylis—Hillman Adducts.

One‐Pot Facile Conversion of the Acetates of Baylis—Hillman Adducts into Substituted Fused Pyrimidones in Aqueous Media.