Tummanapalli Satyanarayana

TL;DR: A novel reaction involving tandem construction of C-N and C-C bonds via the simultaneous Ritter and Houben-Hoesch reactions on Baylis-Hillman adducts leading to a convenient, one-pot synthesis of 2-benzazepine derivatives is described.

TL;DR: In this article, a facile, one-pot convenient transformation of the acetates of Baylis-Hillman adducts into fused pyrimidones, i.e. 3-substituted-1,5-diazabicyclo(4.4.0)deca-2,5,7,9-tetraen-4-ones via reaction with 2-aminopyridine in environmentally friendly aqueous media is described.

TL;DR: The principle of the one-pot multi-substrate screening is presented in this article, which has been successfully applied to various types of catalyzed enantioselective reactions: borane reduction of ketones, addition of organozinc on aldehydes, conjugate addition of diethylzinc on cycloalkenones or nitroal-kenes, hydroformylation of olefins, hetero-Diels-Al-der reaction on α-keto esters, enzymatic hydrolysis of glycerol

TL;DR: In this article, a facile, simple and one-pot conversion of methyl 3-aryl-3-hydroxy-2-methylenepropanoates into methyl (2E)-3-yloyl trifluoromethanesulfonate (TMSOTf) and potassium carbonate/methanol is described.

TL;DR: A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group, which afforded a series of potent orally bioavailable inhibitors of which MK-8718 was identified as a compound with a favorable overall profile.