Tuo Yang

TL;DR: With the development of novel research tools, future research on theBBB is likely to reveal promising potential therapeutic targets for protecting the BBB and improving patient outcome after ischemic stroke.

TL;DR: The clinical importance of ependymal route-based targeted gene therapy and intranasal drug administration in the brain by taking advantage of the unique role played by brain lymphatic pathways in the regulation of CSF flow and ISF/CSF exchange is highlighted.

TL;DR: The therapeutic potential of PPARγ in stroke and brain trauma is reviewed and the novel role of PParγ in long-term tissue repair is highlighted, which lies at the apex of cell fate decisions and exerts profound effects on the chronic progression of acute injury conditions.

TL;DR: This review lists miRNAs that have been reported to regulate various stroke risk factors and pre-disease mechanisms, including hypertension, atherosclerosis, and diabetes, followed by an in-depth analysis of mi RNAs in ischemic stroke pathogenesis, such as excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis and neurogenesis.

TL;DR: A review of recent findings on VCID is summarized, with a focus on vascular age-related pathologies and their contribution to the development of this condition.