T
Turid Aas
Researcher at Haukeland University Hospital
Publications - 64
Citations - 15205
Turid Aas is an academic researcher from Haukeland University Hospital. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 22, co-authored 56 publications receiving 14058 citations. Previous affiliations of Turid Aas include University of Bergen.
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Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
Turid Aas,Anne Lise Børresen,Stephanie Geisler,Birgitte Smith-Sørensen,Hilde Johnsen,Jan Erik Varhaug,Lars A. Akslen,Per Eystein Lønning +7 more
TL;DR: Data is presented linking specific mutations in the P53 gene to primary resistance to doxorubicin therapy and early relapse in breast cancer patients.
Journal ArticleDOI
Subclonal diversification of primary breast cancer revealed by multiregion sequencing
Lucy R. Yates,Moritz Gerstung,Stian Knappskog,Christine Desmedt,Gunes Gundem,Peter Van Loo,Turid Aas,L. Alexandrov,Denis Larsimont,Helen Davies,Yang Li,Young Seok Ju,Manasa Ramakrishna,Hans Kristian Haugland,Peer Kaare Lilleng,Serena Nik-Zainal,Stuart McLaren,Adam Butler,Sancha Martin,Dominic D Glodzik,Andrew Menzies,Keiran Raine,Jonathan Hinton,David T. Jones,Laura Mudie,Bing B Jiang,Delphine Vincent,April Greene-Colozzi,Pierre-Yves Adnet,Aquila Fatima,Marion Maetens,Michail Ignatiadis,Michael R. Stratton,Christos Sotiriou,Andrea L. Richardson,Per Eystein Lønning,David C. Wedge,Peter J. Campbell +37 more
TL;DR: To understand the subclonal structure of primary breast cancer, whole-genome and targeted sequencing was applied to multiple samples from each of 50 patients' tumors, finding thatLandmarks of disease progression arose within detectable subclones of antecedent lesions.
Journal ArticleDOI
Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays
Jonathan R. Pollack,Charles M. Perou,T Sørlie,Ash A. Alizadeh,Christian A. Rees,Michael B. Eise,Alexander Pergamenschikov,Cheryl F. Williams,Matt van de Rijn,Stefanie S. Jeffrey,Hilde Johnsen,Per Eystein Lønning,Stephanie Geisler,Turid Aas,Anne-lise Borresen-Dale,David Botstein,Patrick O. Brown +16 more
TL;DR: In breast cancer cell lines, the cDNA microarray-based comparative genomic hybridisation method is developed, revealing previously unrecognised genomic amplifications and deletions, and new complexities of amplicon structure.
Journal Article
Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer.
Stephanie Geisler,Per Eystein Lønning,Turid Aas,Hilde Johnsen,Øystein Fluge,Dagny Faksvåg Haugen,Johan R. Lillehaug,Lars A. Akslen,Anne Lise Børresen-Dale +8 more
TL;DR: The observation that the majority of patients with TP53 mutations affecting or disrupting the L2/L3 domains with LOH in addition obtained a partial response or stabilization of disease during chemotherapy suggests redundant mechanisms to compensate for loss of p53 function.