D
Delphine Vincent
Researcher at Université libre de Bruxelles
Publications - 60
Citations - 3647
Delphine Vincent is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 23, co-authored 47 publications receiving 3198 citations. Previous affiliations of Delphine Vincent include Australian National University & La Trobe University.
Papers
More filters
Journal ArticleDOI
Subclonal diversification of primary breast cancer revealed by multiregion sequencing
Lucy R. Yates,Moritz Gerstung,Stian Knappskog,Christine Desmedt,Gunes Gundem,Peter Van Loo,Turid Aas,L. Alexandrov,Denis Larsimont,Helen Davies,Yang Li,Young Seok Ju,Manasa Ramakrishna,Hans Kristian Haugland,Peer Kaare Lilleng,Serena Nik-Zainal,Stuart McLaren,Adam Butler,Sancha Martin,Dominic D Glodzik,Andrew Menzies,Keiran Raine,Jonathan Hinton,David T. Jones,Laura Mudie,Bing B Jiang,Delphine Vincent,April Greene-Colozzi,Pierre-Yves Adnet,Aquila Fatima,Marion Maetens,Michail Ignatiadis,Michael R. Stratton,Christos Sotiriou,Andrea L. Richardson,Per Eystein Lønning,David C. Wedge,Peter J. Campbell +37 more
TL;DR: To understand the subclonal structure of primary breast cancer, whole-genome and targeted sequencing was applied to multiple samples from each of 50 patients' tumors, finding thatLandmarks of disease progression arose within detectable subclones of antecedent lesions.
Journal ArticleDOI
Water and salinity stress in grapevines: early and late changes in transcript and metabolite profiles.
Grant R. Cramer,Ali Ergül,Jérôme Grimplet,Richard L. Tillett,Elizabeth A. R. Tattersall,Marlene C. Bohlman,Delphine Vincent,Justin Sonderegger,Jason Evans,Craig Osborne,David R. Quilici,Karen Schlauch,David A. Schooley,John C. Cushman +13 more
TL;DR: Different differences between water deficit and salinity were revealed and water-deficit-treated plants appear to have a higher demand than salinized plants to adjust osmotically, detoxify free radicals (reactive oxygen species), and cope with photoinhibition.
Journal ArticleDOI
Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations
Thierry Rouxel,Jonathan Grandaubert,James K. Hane,Claire Hoede,Angela P. Van de Wouw,Arnaud Couloux,Victoria Dominguez,Véronique Anthouard,Pascal Bally,Salim Bourras,Anton Cozijnsen,Lynda M. Ciuffetti,Alexandre Degrave,Azita Dilmaghani,Laurent Duret,Isabelle Fudal,Stephen B. Goodwin,Lilian Gout,Nicolas Glaser,Juliette Linglin,Gert H. J. Kema,Nicolas Lapalu,Christopher B. Lawrence,Kim May,Michel Meyer,Bénédicte Ollivier,Julie Poulain,Conrad L. Schoch,Adeline Simon,Joseph W. Spatafora,A. Stachowiak,B. Gillian Turgeon,Brett M. Tyler,Delphine Vincent,Jean Weissenbach,Joelle Amselem,Hadi Quesneville,Richard P. Oliver,Patrick Wincker,Marie-Hélène Balesdent,Barbara J. Howlett +40 more
TL;DR: The genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans is reported and its repertoire of protein effectors is characterized, revealing an unusual bipartite structure that underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints.
Journal ArticleDOI
Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer
Françoise Rothé,J-F Laes,Diether Lambrechts,Dominiek Smeets,Delphine Vincent,Marion Maetens,Debora Fumagalli,Stefan Michiels,Stylianos Drisis,Claudine Moerman,J-P Detiffe,Denis Larsimont,Ahmad Awada,Martine Piccart,Christos Sotiriou,Michail Ignatiadis +15 more
TL;DR: Plasma can be prospectively tested as an alternative to metastatic biopsies in molecular screening programs and mutations in both tumor and plasma samples observed were discordant, providing complementary information.
Journal ArticleDOI
Genomic Characterization of Primary Invasive Lobular Breast Cancer
Christine Desmedt,Gabriele Zoppoli,Gunes Gundem,Giancarlo Pruneri,Denis Larsimont,Marco Fornili,Debora Fumagalli,David N Brown,Françoise Rothé,Delphine Vincent,Naima Kheddoumi,Ghizlane Rouas,Samira Majjaj,Sylvain Brohée,Peter Van Loo,Patrick Maisonneuve,Roberto Salgado,Thomas Van Brussel,Diether Lambrechts,Ron Bose,Otto Metzger,Christine Galant,François Bertucci,Martine Piccart-Gebhart,Giuseppe Viale,Elia Biganzoli,Peter J. Campbell,Christos Sotiriou +27 more
TL;DR: This study demonstrates that individualize the treatment of ILBC, with HER2, HER3, and AKT1 mutations representing high-prevalence therapeutic targets and FOXA1 mutations and ESR1 gains deserving urgent dedicated clinical investigation, especially in the context of endocrine treatment.