T
Tyler A Sisley
Researcher at Harvard University
Publications - 7
Citations - 220
Tyler A Sisley is an academic researcher from Harvard University. The author has contributed to research in topics: Chemistry & Gene. The author has an hindex of 3, co-authored 4 publications receiving 95 citations.
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Journal ArticleDOI
Sliding-strip microfluidic device enables ELISA on paper
Mohit S. Verma,Maria-Nefeli Tsaloglou,Tyler A Sisley,Dionysios C. Christodouleas,Austin D. Chen,Jonathan Milette,George M. Whitesides +6 more
TL;DR: 3D microfluidic paper-based analytical device that can be used to conduct an enzyme-linked immunosorbent assay (ELISA) has the technical characteristics to be employed as a pre-screening tool, when combined with other data such as patient history and clinical signs.
Journal ArticleDOI
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
Luke W. Koblan,Mandana Arbab,Mandana Arbab,Mandana Arbab,Max W. Shen,Jeffrey A. Hussmann,Andrew V. Anzalone,Andrew V. Anzalone,Andrew V. Anzalone,Jordan L. Doman,Jordan L. Doman,Jordan L. Doman,Gregory A. Newby,Gregory A. Newby,Gregory A. Newby,Dian Yang,Beverly Mok,Beverly Mok,Beverly Mok,Joseph M. Replogle,Albert Xu,Tyler A Sisley,Jonathan S. Weissman,Britt Adamson,David R. Liu,David R. Liu,David R. Liu +26 more
TL;DR: In this article, a suite of engineered C•G-to-G•C base editors (CGBEs) with machine learning models were used to enable efficient, high-purity C• G-toG-C base editing.
Journal ArticleDOI
At-Home Microscale Paper-Based Quantitative Analysis Activity with External Standards
Viktoria D. E. Schmuck,Isabelle C. Romine,Tyler A Sisley,Chad E. Immoos,Gregory E. Scott,David F. Zigler +5 more
TL;DR: In this article , an inexpensive at-home quantitative analysis activity was developed for the determination of glucose in unknown samples using paper-based microfluidic devices, and the only items students needed to supply were water and a smartphone.
Journal ArticleDOI
Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein
Scott Eagon,Jared T. Hammill,Jordan Bach,Nikalet Everson,Tyler A Sisley,Michael J. Walls,Sierra D. Durham,Dylan R. Pillai,Mofolusho O. Falade,Amy L. Rice,Joshua J. Kimball,Horacio Lazaro,Celine DiBernardo,R. Kiplin Guy +13 more
TL;DR: A rationalized structure based design strategy suggests multiple avenues to further increase potency against the heat shock 90 protein of Plasmodium falciparum, potentially paving the path for a therapeutic with a mode of action different than any current clinical treatment.
Journal ArticleDOI
Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing.
Grzegorz J Grabe,Rachel T. Giorgio,Alexander M J Hall,Rhodri M. L. Morgan,Laurent Dubois,Tyler A Sisley,Julian A Rycroft,Stephen A Hare,Sophie Helaine,Sophie Helaine +9 more
TL;DR: In this paper, the crystal structures of the three TacAT complexes were determined to understand the structural basis of specific TA neutralization and the evolution of such specific pairing, and it was shown that alteration of a discrete structural add-on element on the toxin drives specific recognition by their cognate antitoxin underpinning insulation.