Sophie Helaine

TL;DR: Recent developments in the understanding of bacterial persister cells are discussed and their potential implications for the treatment of persistent infections are discussed.

TL;DR: Scientists working on the response of bacteria to antibiotics define antibiotic persistence and provide practical guidance on how to study bacterial persister cells, and provide a guide to measuring persistence.

TL;DR: The vacuolar environment induces phenotypic heterogeneity, leading to either bacterial replication or the formation of nonreplicating persisters that could provide a reservoir for relapsing infection.

TL;DR: This work reports the development of a reporter system based on fluorescence dilution that enables direct quantification of the replication dynamics of Salmonella enterica serovar Typhimurium in murine macrophages at both the population and single-cell level and finds that, upon entry into macrophage, many bacteria do not replicate, but appear to enter a dormant-like state.

TL;DR: It is shown that Salmonella persisters arising during macrophage infection maintain a metabolically active state, which may confer an advantage to the pathogen during relapse once antibiotic pressure is relieved.