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Tyler J. McCray
Researcher at Indiana University
Publications - 2
Citations - 245
Tyler J. McCray is an academic researcher from Indiana University. The author has contributed to research in topics: Tauopathy & Hyperphosphorylation. The author has an hindex of 2, co-authored 2 publications receiving 165 citations.
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Journal ArticleDOI
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Shane M. Bemiller,Shane M. Bemiller,Shane M. Bemiller,Tyler J. McCray,Kevin C. Allan,Shane Formica,Guixiang Xu,Guixiang Xu,Gina N. Wilson,Olga N. Kokiko-Cochran,Olga N. Kokiko-Cochran,Samuel D. Crish,Cristian A. Lasagna-Reeves,Richard M. Ransohoff,Gary E. Landreth,Gary E. Landreth,Bruce T. Lamb,Bruce T. Lamb +17 more
TL;DR: The results suggest that deficiency of microglial TREM2 leads to heightened tau pathology coupled with widespread increases in activated neuronal stress kinases, and offer new insight into the complex, multiple roles of TREM1 in regulating Aβ and tau pathologies.
Journal ArticleDOI
Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections.
Michael J. Mlodzianoski,Paul J. Cheng-Hathaway,Shane M. Bemiller,Tyler J. McCray,Sheng Liu,David Miller,Bruce T. Lamb,Bruce T. Lamb,Gary E. Landreth,Gary E. Landreth,Fang Huang +10 more
TL;DR: Active PSF shaping and adaptive optics are combined to enable 3D localization microscopy throughout thick tissues and was used to study the nanoscale architecture of amyloid fibrils in a mouse model of Alzheimer’s disease.