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Shane Formica
Researcher at Cleveland Clinic
Publications - 6
Citations - 257
Shane Formica is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: TREM2 & Phagocytosis. The author has an hindex of 4, co-authored 6 publications receiving 165 citations. Previous affiliations of Shane Formica include Cleveland Clinic Lerner Research Institute.
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Journal ArticleDOI
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Shane M. Bemiller,Shane M. Bemiller,Shane M. Bemiller,Tyler J. McCray,Kevin C. Allan,Shane Formica,Guixiang Xu,Guixiang Xu,Gina N. Wilson,Olga N. Kokiko-Cochran,Olga N. Kokiko-Cochran,Samuel D. Crish,Cristian A. Lasagna-Reeves,Richard M. Ransohoff,Gary E. Landreth,Gary E. Landreth,Bruce T. Lamb,Bruce T. Lamb +17 more
TL;DR: The results suggest that deficiency of microglial TREM2 leads to heightened tau pathology coupled with widespread increases in activated neuronal stress kinases, and offer new insight into the complex, multiple roles of TREM1 in regulating Aβ and tau pathologies.
Journal ArticleDOI
Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease.
Rumana Akhter,Yvonne Shao,McKenzie Shaw,Shane Formica,Maria Khrestian,James B. Leverenz,Lynn M. Bekris +6 more
TL;DR: This study shows that miRNA-140-5p has enhanced expression in the AD postmortem brain hippocampus using high-throughput miRNA arrays and quantitative real-time polymerase chain reaction and suggests that dysfunctional regulation of ADAM10 expression is exacerbated by AD-related neurotoxic effects.
Journal ArticleDOI
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Shane M. Bemiller,Shane M. Bemiller,Shane M. Bemiller,Nicole Maphis,Shane Formica,Gina N. Wilson,Crystal M. Miller,Guixiang Xu,Olga N. Kokiko-Cochran,Ki-Wook Kim,Steffen Jung,Judy L. Cannon,Samuel D. Crish,Astrid E. Cardona,Bruce T. Lamb,Kiran Bhaskar +15 more
TL;DR: The data suggest that overexpression of only chemokine domain of CX3CL1 does not protect against tau pathology, which correlated with impaired spatial learning.
Posted ContentDOI
TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells
TL;DR: Treatment of the human microglial cell line, HMC3 cells, was performed and TREM2 was overexpressed or silenced and the phagocytosis, apoptosis and inflammatory response were evaluated, and it was indicated that a robustphagocytic response to Aβ after 24 hours requires TREM3 cells.
Journal ArticleDOI
Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease
Jeffrey A. Zahratka,Yvonne Shao,McKenzie Shaw,Kaitlin Todd,Shane Formica,Maria Khrestian,Thomas J. Montine,James B. Leverenz,Lynn M. Bekris +8 more
TL;DR: It is found that Fyn protein, but not messenger RNA, levels were increased in AD patients compared to cognitively normal controls and are associated with regulatory region single nucleotide polymorphisms, suggesting that FYN expression is regulated according to AD status and regulatory region haplotype.