O
Olga N. Kokiko-Cochran
Researcher at Ohio State University
Publications - 43
Citations - 2633
Olga N. Kokiko-Cochran is an academic researcher from Ohio State University. The author has contributed to research in topics: Traumatic brain injury & Neuroinflammation. The author has an hindex of 17, co-authored 33 publications receiving 1817 citations. Previous affiliations of Olga N. Kokiko-Cochran include Cleveland Clinic Lerner Research Institute & Virginia Commonwealth University.
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Journal ArticleDOI
Regulation of tau pathology by the microglial fractalkine receptor
Kiran Bhaskar,Megan E. Konerth,Olga N. Kokiko-Cochran,Astrid E. Cardona,Richard M. Ransohoff,Bruce T. Lamb,Bruce T. Lamb +6 more
TL;DR: The results suggest that CX3CR1 and IL-1/p38 MAPK may serve as novel therapeutic targets for human tauopathies.
Journal ArticleDOI
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
Nicole Maphis,Guixiang Xu,Olga N. Kokiko-Cochran,Shanya Jiang,Astrid E. Cardona,Richard M. Ransohoff,Bruce T. Lamb,Kiran Bhaskar +7 more
TL;DR: The results suggest that reactive microglia are sufficient to drive tau pathology and correlate with the spread of pathological tau in the brain.
Journal ArticleDOI
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Chad A. Tagge,Andrew M. Fisher,Olga Minaeva,Amanda Gaudreau-Balderrama,Juliet A. Moncaster,Xiao-Lei Zhang,Mark W. Wojnarowicz,Noel Casey,Haiyan Lu,Olga N. Kokiko-Cochran,Sudad Saman,Maria Ericsson,Kristen D. Onos,Ronel Veksler,Vladimir V. Senatorov,Asami Kondo,Xiao Z. Zhou,Omid Miry,Linnea R. Vose,Katisha R. Gopaul,Chirag Upreti,Christopher J. Nowinski,Robert C. Cantu,Robert C. Cantu,Victor E. Alvarez,Victor E. Alvarez,Audrey M. Hildebrandt,Erich S. Franz,Janusz Konrad,James A. Hamilton,Ning Hua,Yorghos Tripodis,Andrew T. Anderson,Gareth R. Howell,Daniela Kaufer,Daniela Kaufer,Garth F. Hall,Kun P. Lu,Richard M. Ransohoff,Robin O. Cleveland,Neil W. Kowall,Neil W. Kowall,Thor D. Stein,Thor D. Stein,Bruce T. Lamb,Bertrand R. Huber,William C. Moss,Alon Friedman,Alon Friedman,Patric K. Stanton,Ann C. McKee,Ann C. McKee,Lee E. Goldstein +52 more
TL;DR: Using neuropathological analyses of brains from teenage athletes, a new mouse model of concussive impact injury, and computational simulations, Tagge and colleagues show that head injuries can induce TBI and early CTE pathologies independent of concussion.
Journal ArticleDOI
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Shane M. Bemiller,Shane M. Bemiller,Shane M. Bemiller,Tyler J. McCray,Kevin C. Allan,Shane Formica,Guixiang Xu,Guixiang Xu,Gina N. Wilson,Olga N. Kokiko-Cochran,Olga N. Kokiko-Cochran,Samuel D. Crish,Cristian A. Lasagna-Reeves,Richard M. Ransohoff,Gary E. Landreth,Gary E. Landreth,Bruce T. Lamb,Bruce T. Lamb +17 more
TL;DR: The results suggest that deficiency of microglial TREM2 leads to heightened tau pathology coupled with widespread increases in activated neuronal stress kinases, and offer new insight into the complex, multiple roles of TREM1 in regulating Aβ and tau pathologies.
Journal ArticleDOI
Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events.
Kiran Bhaskar,Nicole Maphis,Guixiang Xu,Nicholas H. Varvel,Olga N. Kokiko-Cochran,Jason P. Weick,Susan M. Staugaitis,Astrid E. Cardona,Richard M. Ransohoff,Karl Herrup,Bruce T. Lamb +10 more
TL;DR: A cell-autonomous role of microglia is suggested, TNFα is identified as the responsible cytokine, in promoting neuronal CCEs in the pathogenesis of AD, and a portion of these neurons are apoptotic.