T
Tzu-Ming Wang
Researcher at Genentech
Publications - 15
Citations - 892
Tzu-Ming Wang is an academic researcher from Genentech. The author has contributed to research in topics: Lipid bilayer fusion & Vesicle. The author has an hindex of 12, co-authored 15 publications receiving 654 citations. Previous affiliations of Tzu-Ming Wang include University of Texas Southwestern Medical Center & National Taiwan University.
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Journal ArticleDOI
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
Tiffany Wu,Borislav Dejanovic,Vineela D. Gandham,Alvin Gogineni,Rose Edmonds,Stephen P. Schauer,Karpagam Srinivasan,Melanie A. Huntley,Yuanyuan Wang,Tzu-Ming Wang,Maj Hedehus,Kai H. Barck,Maya Stark,Hai Ngu,Oded Foreman,William J. Meilandt,Justin Elstrott,Michael C. Chang,David V. Hansen,Richard A.D. Carano,Morgan Sheng,Jesse E. Hanson +21 more
TL;DR: It is demonstrated that complement activation contributes to neurodegeneration caused by tau pathology and suggested that blocking C3 function might be protective in AD and other tauopathies.
Journal ArticleDOI
SNARE-Mediated Lipid Mixing Depends on the Physical State of the Vesicles
TL;DR: Reconstitution of solubilized neuronal SNAREs into preformed 100 nm liposomes (direct method) yields proteoliposomes with more homogeneous sizes and protein densities than the standard reconstitution method involving detergent cosolubilization of proteins and lipids.
Journal ArticleDOI
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
David H. Hackos,Patrick J. Lupardus,Teddy Grand,Yelin Chen,Tzu-Ming Wang,Paul Reynen,Amy Gustafson,Heidi J.A. Wallweber,Matthew Volgraf,Benjamin D. Sellers,Jacob Schwarz,Pierre Paoletti,Morgan Sheng,Qiang Zhou,Jesse E. Hanson +14 more
TL;DR: The identification of a new NMDAR modulatory site and characterization of GluN2A-selective PAMs provide powerful molecular tools to dissect N MDAR function and demonstrate the feasibility of a therapeutically desirable type of NMD AR enhancement.
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Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
Matthew Volgraf,Benjamin D. Sellers,Jiang Yu,Guosheng Wu,Cuong Ly,Elisia Villemure,Richard Pastor,Yuen Po-Wai,Aijun Lu,Xifeng Luo,Mingcui Liu,Shun Zhang,Liang Sun,Yuhong Fu,Patrick J. Lupardus,Heidi J.A. Wallweber,Bianca M. Liederer,Gauri Deshmukh,Emile Plise,Suzanne Tay,Paul Reynen,James B Herrington,Amy Gustafson,Yichin Liu,Akim Dirksen,Matthias G. A. Dietz,Yanzhou Liu,Tzu-Ming Wang,Jesse E. Hanson,David H. Hackos,Kimberly Scearce-Levie,Jacob Bradley Schwarz +31 more
TL;DR: Using structure-based design, this work sought to increase potency at the GluN2A subtype, while improving selectivity against related α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) using a combination of electrophysiology and protein crystallography.
Journal ArticleDOI
Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina
TL;DR: It is shown that light elicits a change in synaptic proton concentration with the correct magnitude, kinetics and spatial dependence to account for lateral inhibition, and the possibility that protons are unrecognized retrograde messengers elsewhere in the nervous system is raised.