Udayan Chatterji

TL;DR: The respective contribution of Cyp members to HCV replication is analyzed by specifically knocking down their expression by both transient and stable small RNA interference, suggesting for the first time that HCV exploits either the isomerase or the chaperone activity of CypA to replicate in hepatocytes and that CypA is the principal mediator of the Cyp inhibitor anti-HCV activity.

TL;DR: It was very difficult to select resistant replicons (genotype 1b) to DEB025, requiring an average of 20 weeks (four independent experiments), compared to the typically <2 weeks with protease or polymerase inhibitors, indicating a high genetic barrier to resistance forDEB025.

TL;DR: The transcellular migration of HIV-1 as a cell-free virus through primary genital epithelial cells (PGECs) is investigated and it is found that syndecans are abundantly expressed on PGECs and promote the initial attachment and subsequent entry of HIV, which demonstrates that the genital epithelium serves as a major barrier against HIV- 1.

TL;DR: Dendritic cells efficiently capture HIV-1 and mediate transmission to T cells, but the underlying molecular mechanism is still being debated, and an effective microbicide should target both syndecan-3 and DC-SIGN on DCs to prevent transmission.

TL;DR: It is shown that CypA, via its isomerase pocket, binds directly to NS5A, and most importantly, that disrupting this interaction stops HCV replication.