Ugur Akar

TL;DR: The role of Bcl-2 in autophagy in breast cancer cells is investigated and silencing of B cl-2 by siRNA led to induction of LC-3-II, a hallmark ofAutophagy, ATG5 and Beclin-1 autophile promoting proteins.

TL;DR: Evidence is provided that protein kinase Cδ (PKCδ) regulates TG2 expression, which in turn inhibits autophagy, a type II programmed cell death, in pancreatic cancer cells that are frequently insensitive to standard chemotherapeutic agents.

TL;DR: Overall prognosis of TNBC in BRCA carriers and non-carriers is not significantly different within the first 5 years following an initial diagnosis, and data indicate a 50% prevalence of deleterious BRCa1/2 mutations in high-risk women diagnosed with TNBC.

TL;DR: It is suggested that PDCD4 expression contributes to ATRA-induced granulocytic but not monocytic/macrophagic differentiation.

TL;DR: The data provide the first evidence that in vivo therapeutic targeting Bcl-2 by systemically administered nanoliposomal-siRNA significantly inhibits growth of both ER(−) and ER(+) breast tumors and enhances the efficacy of chemotherapy, suggesting that therapeutic silencing of Bcl -2 by siRNA is a viable approach in breast cancers.