S
Seiji Kondo
Researcher at University of Texas MD Anderson Cancer Center
Publications - 96
Citations - 12134
Seiji Kondo is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Apoptosis & Glioma. The author has an hindex of 53, co-authored 95 publications receiving 11532 citations. Previous affiliations of Seiji Kondo include Mount Sinai Hospital & Baylor College of Medicine.
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Journal ArticleDOI
The role of autophagy in cancer development and response to therapy
TL;DR: It is still unclear whether autophagy suppresses tumorigenesis or provides cancer cells with a rescue mechanism under unfavourable conditions, and how can the autophagic process be manipulated to improve anticancer therapeutics.
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The Energy Sensing LKB1-AMPK Pathway Regulates p27kip1 Phosphorylation Mediating the Decision to Enter Autophagy or Apoptosis
Jiyong Liang,Shan H. Shao,Shan H. Shao,Zhi-Xiang Xu,Bryan T. Hennessy,Zhiyong Ding,Michelle D. Larrea,Seiji Kondo,Daniel J. Dumont,Jordan U. Gutterman,Cheryl L. Walker,Joyce M. Slingerland,Gordon B. Mills +12 more
TL;DR: LKB1–AMPK pathway-dependent phosphorylation of p27 at Thr 198 stabilizes p27 and permits cells to survive growth factor withdrawal and metabolic stress through autophagy, which may contribute to tumour-cell survival under conditions of growth factor deprivation, disrupted nutrient and energy metabolism, or during stress of chemotherapy.
Journal Article
Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.
TL;DR: The findings suggest that As(2)O(3) at a clinically safe concentration may be an effective chemotherapeutic agent for malignant gliomas.
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Synergistic Augmentation of Rapamycin-Induced Autophagy in Malignant Glioma Cells by Phosphatidylinositol 3-Kinase/Protein Kinase B Inhibitors
Hayato Takeuchi,Yasuko Kondo,Keishi Fujiwara,Takao Kanzawa,Hiroshi Aoki,Gordon B. Mills,Seiji Kondo,Seiji Kondo +7 more
TL;DR: The results indicate that rapamycin exerts its antitumor effect on malignant glioma cells by inducing autophagy and suggest that in malignantgliomas cells a disruption of the PI3K/Akt signaling pathway could greatly enhance the effectiveness of mTOR inhibitors.
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Evidence That Curcumin Suppresses the Growth of Malignant Gliomas in Vitro and in Vivo through Induction of Autophagy: Role of Akt and Extracellular Signal-Regulated Kinase Signaling Pathways
Hiroshi Aoki,Yasunari Takada,Seiji Kondo,Seiji Kondo,Seiji Kondo,Raymond Sawaya,Bharat B. Aggarwal,Yasuko Kondo +7 more
TL;DR: It is suggested that curcumin has high anticancer efficacy in vitro and in vivo by inducing autophagy and warrant further investigation toward possible clinical application in patients with malignant glioma.