Ulf Rannug

TL;DR: Whether ultraviolet light (UV) irradiation of amino acids produces compounds with affinity for the Ah receptor is determined and the existence of high affinity receptors for oxidized amino acids is postulated and their possible role in the proliferative cellular responses to TCDD and tryptophan is discussed briefly.

TL;DR: These findings indicate that formylindolo[3,2-b]carbazols are the most potent naturally occurring activators of the AhR signaling pathway and may be the key substrates of the CYP1 and SULT1 families of enzymes.

TL;DR: It is concluded that 1,2-dichloroethane is activated by conjugation to glutathione, which gives a weak direct mutagenic effect, which is enhanced by addition of the postmitochondrial liver fraction (S-9).

TL;DR: The elucidation of the structures of the two high affinity Ah receptor ligands 6,12-diformylindolo[3,2-b]carbazole and 6-formylindol[3-2- b]carbzole provides the necessary basis for further mechanistic studies of this important group of compounds, and will help in determining the natural role of the Ah receptor.

TL;DR: It is proposed that prolonged induction of AHR activity through inhibition of CYP1 disturbs feedback regulation of FICZ levels, with potential detrimental consequences, and raised questions about the reported promiscuity of the AHR.