U
Ulrich Brandt
Researcher at Radboud University Nijmegen
Publications - 216
Citations - 17870
Ulrich Brandt is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Respiratory chain & Protein subunit. The author has an hindex of 73, co-authored 208 publications receiving 16124 citations. Previous affiliations of Ulrich Brandt include Goethe University Frankfurt & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Cardiolipin stabilizes respiratory chain supercomplexes.
Kathy Pfeiffer,Vishal M. Gohil,Rosemary A. Stuart,Carola Hunte,Ulrich Brandt,Miriam L. Greenberg,Hermann Schägger +6 more
TL;DR: It is shown that a cardiolipin-deficient strain harbored almost inactive resting cytochrome c oxidase in the membrane and Transition to the fully active pulsed state occurred on a minute time scale.
Journal ArticleDOI
Energy Converting NADH: Quinone Oxidoreductase (Complex I)
TL;DR: The coupling mechanism of complex I most likely involves semiquinone intermediates that drive proton pumping through redox-linked conformational changes.
Journal ArticleDOI
Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice
Virginie Rhein,Xiaomin Song,Andreas Wiesner,Lars M. Ittner,G. Baysang,Fides Meier,Laurence Ozmen,Horst Bluethmann,Stefan Dröse,Ulrich Brandt,Egemen Savaskan,Christian Czech,Jürgen Götz,Anne Eckert +13 more
TL;DR: A molecular link between Aβ and tau protein in AD pathology in vivo is established, illustrating the potential of quantitative proteomics and establishing synergistic, age-associated effects of A β and t Tau in perishing mitochondria.
Book ChapterDOI
Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain
Stefan Dröse,Ulrich Brandt +1 more
TL;DR: A detailed understanding of the molecular mechanisms driving these enzymes is required to understand mitochondrial ROS production during oxidative stress and redox signalling.
Journal ArticleDOI
Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice.
Susanne Hauptmann,Isabel Scherping,Stefan Dröse,Ulrich Brandt,Kathrin Schulz,Marina Jendrach,Kristina Leuner,Anne Eckert,Walter E. Müller +8 more
TL;DR: It is concluded that Ass dependent mitochondrial dysfunction starts already at 3 months in this AD model before extracellular deposition of Ass and progression accelerates substantially with aging.