U
Ulrike Laugks
Researcher at Max Planck Society
Publications - 19
Citations - 449
Ulrike Laugks is an academic researcher from Max Planck Society. The author has contributed to research in topics: Synaptic vesicle & Chemistry. The author has an hindex of 7, co-authored 13 publications receiving 301 citations.
Papers
More filters
Journal ArticleDOI
Electron cryotomography of vitrified cells with a Volta phase plate
TL;DR: After 3D reconstruction, tomograms acquired with the combination of a VPP and an energy filter showed structural features in neuronal processes with outstanding clarity, and it is expected that VPP will become a standard element of the electron cryotomography workflow.
Journal ArticleDOI
Synucleins Have Multiple Effects on Presynaptic Architecture
Karina J. Vargas,Nikolas Schrod,Taylor Davis,Rubén Fernández-Busnadiego,Rubén Fernández-Busnadiego,Yumiko V. Taguchi,Ulrike Laugks,Vladan Lucic,Sreeganga S. Chandra +8 more
TL;DR: It is shown that synucleins are regulators of presynapse size and synaptic vesicle (SV) pool organization and that α-synuclein PD mutants primarily affected presynaptic cytomatrix proximal to the active zone.
Journal ArticleDOI
Template-free detection and classification of membrane-bound complexes in cryo-electron tomograms.
Antonio Martinez-Sanchez,Zdravko Kochovski,Ulrike Laugks,Johannes Meyer zum Alten Borgloh,Sudeshna Das Chakraborty,Stefan Pfeffer,Wolfgang Baumeister,Vladan Lucic +7 more
TL;DR: A template-free image processing procedure for accurate tracing of complex networks of densities in cryo-electron tomograms, a comprehensive and automated detection of heterogeneous membrane-bound complexes and an unsupervised classification (PySeg) and applications to intact cells and isolated endoplasmic reticulum.
Journal ArticleDOI
Pleomorphic linkers as ubiquitous structural organizers of vesicles in axons.
Nikolas Schrod,Dimitri Vanhecke,Ulrike Laugks,Valentin Stein,Yoshiyuki Fukuda,Miroslava Schaffer,Wolfgang Baumeister,Vladan Lucic +7 more
TL;DR: It is established that neurons grown in culture provide a suitable system for in situ structural investigations of cellular structures by cryo-electron tomography, a method that allows high resolution, three-dimensional imaging of fully hydrated, vitrified cellular samples.
Journal ArticleDOI
Hierarchical detection and analysis of macromolecular complexes in cryo-electron tomograms using Pyto software
TL;DR: The methods presented provide a means for the detection and quantitative interpretation of structures captured in cryo-electron tomograms, as well as for the elucidation of their cellular function.