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Yumiko V. Taguchi
Researcher at Yale University
Publications - 5
Citations - 308
Yumiko V. Taguchi is an academic researcher from Yale University. The author has contributed to research in topics: Health care & Medicine. The author has an hindex of 3, co-authored 3 publications receiving 219 citations.
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Journal ArticleDOI
Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
Yumiko V. Taguchi,Jun Liu,Jiapeng Ruan,Joshua Pacheco,Xiaokui Zhang,Justin Abbasi,Joan Keutzer,Pramod K. Mistry,Sreeganga S. Chandra +8 more
TL;DR: It is proposed that glucosylsphingosine, a sphingolipid accumulating in GD, mediates PD pathology in GBA-associated PD, and data indicate that ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosysphingoine production and metabolism are attractive therapeutic targets for treating mutant GBA -associated PD.
Journal ArticleDOI
Synucleins Have Multiple Effects on Presynaptic Architecture
Karina J. Vargas,Nikolas Schrod,Taylor Davis,Rubén Fernández-Busnadiego,Rubén Fernández-Busnadiego,Yumiko V. Taguchi,Ulrike Laugks,Vladan Lucic,Sreeganga S. Chandra +8 more
TL;DR: It is shown that synucleins are regulators of presynapse size and synaptic vesicle (SV) pool organization and that α-synuclein PD mutants primarily affected presynaptic cytomatrix proximal to the active zone.
Journal ArticleDOI
Hsp110 mitigates α-synuclein pathology in vivo.
Yumiko V. Taguchi,Erica L. Gorenberg,Maria Nagy,Drake R. Thrasher,Wayne A. Fenton,Laura A. Volpicelli-Daley,Arthur L. Horwich,Sreeganga S. Chandra +7 more
TL;DR: It is shown that overexpressing Hsp110, a limiting component of the disaggregase, is beneficial in reducing α-synuclein fibrillar pathology in 2 distinct mouse models of Parkinson’s disease and that overexpression of the chaperone Hsp 110 is sufficient to reduce α- synuclein aggregation in a mammalian cell culture model.
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Ep1001: medicare reimbursement of gastrointestinal procedures from 2000 to 2021
Journal ArticleDOI
Direct care TeleDiabetes practice in the Phoenix VA healthcare system: Innovation report.
TL;DR: The Phoenix Veterans Affairs Healthcare System implemented a TeleDiabetes program in 2018 to provide multidisciplinary care to rural Veterans with type 2 diabetes as discussed by the authors , which is a novel telemedicine model with integrated remote physical exam.