U
Ulrike Müller
Researcher at Heidelberg University
Publications - 194
Citations - 17349
Ulrike Müller is an academic researcher from Heidelberg University. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 61, co-authored 183 publications receiving 15888 citations. Previous affiliations of Ulrike Müller include Leipzig University & University of Zurich.
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Journal ArticleDOI
Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo
Peter Jedlicka,Mirka Owen,Matej Vnencak,Jakob-A. Tschäpe,Meike Hick,Ulrike Müller,Thomas Deller +6 more
TL;DR: It is suggested that the deletion of APP may affect presynaptic plasticity of synaptic transmission at the perforant path–granule cell synapse but leaves synaptic efficacy intact and LTP preserved, possibly due to functional redundancy within the APP gene family.
Journal ArticleDOI
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Vicky Steubler,Susanne Erdinger,Michaela K Back,Susann Ludewig,Dominique Fässler,Max Richter,Kang Han,Lutz Slomianka,Irmgard Amrein,Jakob von Engelhardt,David P. Wolfer,David P. Wolfer,Martin Korte,Ulrike Müller +13 more
TL;DR: In this article, the authors identify essential functions of the APP family during development, for normal hippocampal function and circuits important for learning and social behavior, including repetitive rearing and climbing, impaired social communication and deficits in social interaction.
Journal ArticleDOI
In vivo Ca2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria.
Elena Montagna,Elena Montagna,Sophie Crux,Sophie Crux,Manja Luckner,Julia Herber,Julia Herber,Alessio Colombo,Petar Marinković,Sabina Tahirovic,Stefan F. Lichtenthaler,Stefan F. Lichtenthaler,Stefan F. Lichtenthaler,Gerhard Wanner,Ulrike Müller,Carmelo Sgobio,Jochen Herms,Jochen Herms +17 more
TL;DR: A prominent role of APP is highlighted in the modulation of Ca2+ activity in astrocytic microdomains whose precise functioning is crucial for the reinforcement and modulation of synaptic function.
Journal ArticleDOI
APP accumulates with presynaptic proteins around amyloid plaques: A role for presynaptic mechanisms in Alzheimer's disease?
Tomàs Jordà-Siquier,Melina Petrel,Vladimir Kouskoff,Una Smailovic,Fabrice P. Cordelières,Susanne Frykman,Ulrike Müller,Christophe Mulle,Gael Barthet +8 more
TL;DR: Investigation of the distribution of APP in human AD brain samples and in mouse models of AD finds that alteration of APP distribution and its accumulation together with presynaptic proteins around dense-core amyloid plaques is a key histopathological feature in AD, lending support to the notion that Presynaptic failure is a strong physiopathological component of AD.
Journal ArticleDOI
Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.
Matej Vnencak,Mandy H. Paul,Meike Hick,Stephan W. Schwarzacher,Domenico Del Turco,Ulrike Müller,Thomas Deller,Peter Jedlicka +7 more
TL;DR: It is concluded that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus.