D
Domenico Del Turco
Researcher at Goethe University Frankfurt
Publications - 58
Citations - 6205
Domenico Del Turco is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Dentate gyrus & Granule cell. The author has an hindex of 31, co-authored 55 publications receiving 5559 citations. Previous affiliations of Domenico Del Turco include University of Freiburg.
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Journal ArticleDOI
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Eriza Maria Valente,Patrick M. Abou-Sleiman,Viviana Caputo,Miratul M. K. Muqit,Kirsten Harvey,Suzana Gispert,Zeeshan Ali,Domenico Del Turco,Anna Rita Bentivoglio,Daniel G. Healy,Alberto Albanese,Robert L. Nussbaum,Rafael González-Maldonado,Thomas Deller,S Salvi,Pietro Cortelli,William P. Gilks,David S. Latchman,Roberk J. Harvey,Bruno Dallapiccola,Georg Auburger,Nicholas W. Wood +21 more
TL;DR: The identification of two homozygous mutations affecting the PINK1 kinase domain in three consanguineous PARK6 families provide a direct molecular link between mitochondria and the pathogenesis of PD.
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Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation
Kirsten Ridder,Sascha Keller,Maria Dams,Anne-Kathleen Rupp,Jessica Schlaudraff,Domenico Del Turco,Julia Starmann,Jadranka Macas,Darja Karpova,Kavi Devraj,Candan Depboylu,Britta Landfried,Bernd Arnold,Karl H. Plate,Günter U. Höglinger,Holger Sültmann,Peter Altevogt,Stefan Momma +17 more
TL;DR: When stimulated by inflammation, peripheral blood cells signal directly to neurons in the brain via the transfer of functional RNA enclosed in extracellular vesicles.
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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6
Hans-Hermann Hoepken,Suzana Gispert,Blas Morales,Oliver Wingerter,Domenico Del Turco,Alexander Mülsch,Robert L. Nussbaum,Klaus Müller,Stefan Dröse,Ulrich Brandt,Thomas Deller,Brunhilde Wirth,Alexei P. Kudin,Wolfram S. Kunz,Georg Auburger +14 more
TL;DR: Genetic data indicate that PINK1 function is critical to prevent oxidative damage and that peripheral cells may be useful for studies of progression and therapy of PARK6.
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Transgenic mice expressing mutant A53T human alpha-synuclein show neuronal dysfunction in the absence of aggregate formation
Suzana Gispert,Domenico Del Turco,Lisa Garrett,Amy Chen,David J. Bernard,John Hamm-Clement,Horst-Werner Korf,Thomas Deller,Heiko Braak,Georg Auburger,Robert L. Nussbaum +10 more
TL;DR: Transgenic mice expressing mutant alpha-synuclein may be a valuable model to assess specific aspects of the pathogenesis of synucleinopathies and show progressive reduction of spontaneous vertical motor activity in both mutant lines correlating with the dosage of overexpression.
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AnkyrinG is required to maintain axo-dendritic polarity in vivo
Jürgen-Markus Sobotzik,Jana Maria Sie,Chrisoula Politi,Domenico Del Turco,Vann Bennett,Thomas Deller,Christian Schultz +6 more
TL;DR: It is demonstrated that nonspiny PC axons of EGFP-positive/ankG−/− mice acquire a spiny phenotype within a time range of only 3 days, and ankG thus is important for maintaining appropriate axo-dendritic polarity in vivo.