Ulrike Müller

TL;DR: Using an in vitro cell-adhesion assay, it is observed that APP trans-dimerization is considerably less efficient than APLP2 trans-interaction, which suggests differences between APP/APLP2 and APP/ APLP1 NMJ formation may be in part explained by differences in APP/apLP2Trans-Dimerization properties.

TL;DR: Shared transcriptome profiles corroborated closely related physiological functions of APP family members in the adult central nervous system and revealed that background-related transcriptome changes may dominate over changes due to the knockout of a single gene.

TL;DR: A significant functional role of APP and amyloid precursor‐like protein 2 (APLP2) in the development of synaptic function by the regulation of glutamatergic neurotransmission is indicated.

Abstract: The high-temperature syntheses of the low-valent halogenides P2I4, Te2Br, a-Te4I4, Te4(Al2Cl7)2, Te4(Bi6Cl20), Te8(Bi4Cl14), Bi8(AlCl4)2, Bi6Cl7, and Bi6Br7, as well as of WSCl4 and WOCl4 have been replaced by resource-efficient low-temperature syntheses in room temperature ionic liquids (RTILs). The simple one-pot syntheses generally do not require elaborate equipment such as two zone furnaces or evacuated silica ampoules. Compared to the published conventional approaches, reduction of reaction time (up to 80%) and temperature (up to 500 K) and, simultaneously, an increase in yield were achieved. In the majority of cases, the solid products were phase-pure. X-Ray diffraction on single crystals (redetermination of 11 crystal structures) has demonstrated that the quality of the crystals from RTILs is comparable to that of products obtained by chemical transport reactions. Graphical Abstract Substitution of Conventional High-temperature Syntheses of Inorganic Compounds by Near-room-temperature Syntheses in Ionic Liquids

TL;DR: The reduced 12-item WOMAC is demonstrated to have internal construct validity for assessing patients with FAI and OA on the same scale and high internal consistency reliability.