U
Ursula B. Kaiser
Researcher at Brigham and Women's Hospital
Publications - 232
Citations - 16273
Ursula B. Kaiser is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Gonadotropin-releasing hormone & Receptor. The author has an hindex of 62, co-authored 210 publications receiving 14115 citations. Previous affiliations of Ursula B. Kaiser include University of Pennsylvania & St. Michael's Hospital.
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Journal ArticleDOI
Pulsatile gonadotropin-releasing hormone therapy is associated with earlier spermatogenesis compared to combined gonadotropin therapy in patients with congenital hypogonadotropic hypogonadism.
Jiangfeng Mao,Zhaoxiang Liu,Min Nie,Xi Wang,Hongli Xu,Bingkun Huang,Junjie Zheng,Le Min,Ursula B. Kaiser,Xueyan Wu +9 more
TL;DR: It is found that pulsatile GnRH therapy was associated with earlier spermatogenesis and larger testicular size compared to combined gonadotropin therapy and additional prospective randomized studies would be required to confirm these findings.
Journal ArticleDOI
The Role of Prokineticins in the Pathogenesis of Hypogonadotropic Hypogonadism
TL;DR: Evidence from several naturally inactivating mutations in the PROK2 and PROKR2 genes in patients with Kallmann syndrome and normosmic hypogonadotropic hypog ongonadism indicate the essential role of PRok2 in olfactory bulb morphogenesis and GnRH secretion in humans.
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Genotype-Phenotype Correlations in Central Precocious Puberty Caused by MKRN3 Mutations.
Carlos Eduardo Seraphim,Ana Pinheiro Machado Canton,Luciana Ribeiro Montenegro,Maiara Ribeiro Piovesan,Delanie B Macedo,Marina Cunha,Aline Guimaraes,Carolina Ramos,Anna Flavia Figueiredo Benedetti,Andrea de Castro Leal,Priscila Gagliardi,Sonir Roberto Rauber Antonini,Mirta Gryngarten,Andrea Arcari,Ana Paula Abreu,Ursula B. Kaiser,Leandro Soriano-Guillén,Arancha Escribano-Muñoz,Raquel Corripio,José I Labarta,Lourdes Travieso-Suárez,Nelmar Valentina Ortiz-Cabrera,Jesús Argente,Berenice B. Mendonca,Vinicius Nahime Brito,Ana Claudia Latronico +25 more
TL;DR: In this paper, the authors describe the clinical and hormonal features of a large cohort of patients with CPP due to makorin RING finger protein 3 (MKRN3) mutations and compare the characteristics of different types of genetic defects.
Journal ArticleDOI
The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients.
TL;DR: None of the treated patients revealed any mutation, suggesting that the glucocorticoid receptor in the CLL patients tested is not altered in these domains, and mechanisms other than altered ligand or DNA binding of the receptor may be responsible for the lack of response to chemotherapy.
Journal ArticleDOI
GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion
Andy V. Babwah,Víctor M. Navarro,Maryse R. Ahow,Macarena Pampillo,Connor P. Nash,Mehri Fayazi,Michele D. Calder,Adrienne Elbert,Henryk F. Urbanski,Nina Wettschureck,Stefan Offermanns,Rona S. Carroll,Moshmi Bhattacharya,Stuart A. Tobet,Ursula B. Kaiser +14 more
TL;DR: It is concluded that the milder reproductive phenotypes and maintained responsiveness to KP and gonadotropins reflect Gαq/11-independent GnRH secretion and activation of the neuroendocrine-reproductive axis in Gnaqd/d mice.