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Utkarsh Acharya
Researcher at University of Washington
Publications - 43
Citations - 1309
Utkarsh Acharya is an academic researcher from University of Washington. The author has contributed to research in topics: Medicine & Chimeric antigen receptor. The author has an hindex of 13, co-authored 38 publications receiving 804 citations. Previous affiliations of Utkarsh Acharya include St. Vincent Mercy Medical Center & Heritage College of Osteopathic Medicine.
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Journal ArticleDOI
Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy.
Kevin A. Hay,Kevin A. Hay,Jordan Gauthier,Alexandre V. Hirayama,Jenna M. Voutsinas,Qian Wu,Daniel Li,Ted Gooley,Sindhu Cherian,Xueyan Chen,Barbara S. Pender,Reed M. Hawkins,Aesha Vakil,Rachel N. Steinmetz,Gary Schoch,Aude G. Chapuis,Aude G. Chapuis,Brian G. Till,Brian G. Till,Hans-Peter Kiem,Hans-Peter Kiem,Jorge Ramos,Jorge Ramos,Mazyar Shadman,Mazyar Shadman,Ryan D. Cassaday,Ryan D. Cassaday,Utkarsh Acharya,Utkarsh Acharya,Stanley R. Riddell,Stanley R. Riddell,David G. Maloney,David G. Maloney,Cameron J. Turtle,Cameron J. Turtle +34 more
TL;DR: Patients with relapsed/refractory B-ALL enrolled in a phase 1/2 clinical trial evaluating lymphodepletion chemotherapy followed by CD19 CAR T-cell therapy who might benefit from consolidation strategies such as allogeneic HCT are studied.
Journal ArticleDOI
The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.
Alexandre V. Hirayama,Jordan Gauthier,Kevin A. Hay,Kevin A. Hay,Jenna M. Voutsinas,Qian Wu,Ted Gooley,Daniel Li,Sindhu Cherian,Xueyan Chen,Barbara S. Pender,Reed M. Hawkins,Aesha Vakil,Rachel N. Steinmetz,Utkarsh Acharya,Utkarsh Acharya,Ryan D. Cassaday,Ryan D. Cassaday,Aude G. Chapuis,Aude G. Chapuis,Tejaswini Dhawale,Paul C. Hendrie,Hans-Peter Kiem,Hans-Peter Kiem,Ryan C. Lynch,Ryan C. Lynch,J L Ramos,J L Ramos,Mazyar Shadman,Mazyar Shadman,Brian G. Till,Brian G. Till,Stanley R. Riddell,Stanley R. Riddell,David G. Maloney,David G. Maloney,Cameron J. Turtle,Cameron J. Turtle +37 more
TL;DR: Analysis of clinical and treatment characteristics, serum biomarkers, and CAR T-cell manufacturing and pharmacokinetic data showed that a lower pre-lymphodepletion serum lactate dehydrogenase (LDH) level and a favorable cytokine profile, defined as serum day 0 monocyte chemoattractant protein-1 (MCP-1) and peak interleukin-7 (IL-7) concentrations above the median, were associated with better PFS.
Journal ArticleDOI
Axicabtagene Ciloleucel in the Non-Trial Setting: Outcomes and Correlates of Response, Resistance, and Toxicity
Caron A. Jacobson,Bradley D. Hunter,Robert A. Redd,Scott J. Rodig,Pei Hsuan Chen,Kyle Wright,Mikel Lipschitz,Jerome Ritz,Yusuke Kamihara,Philippe Armand,Sarah Nikiforow,Michael Rogalski,Joseph E. Maakaron,Samantha Jaglowski,Marcela V. Maus,Yi-Bin Chen,Jeremy S. Abramson,Justin Kline,Elizabeth Budde,Alex F. Herrera,Matthew Mei,Jonathon B. Cohen,Stephen D. Smith,David G. Maloney,Ajay K. Gopal,Matthew J. Frigault,Utkarsh Acharya,Utkarsh Acharya +27 more
TL;DR: Axi-cel yields similar rates of overall response and toxicity in commercial and trial settings, although CR rates and DOR were more favorable in patients eligible for ZUMA-1.
Journal ArticleDOI
Risk of Atrial Fibrillation and Bleeding Diathesis Associated With Ibrutinib Treatment: A Systematic Review and Pooled Analysis of Four Randomized Controlled Trials
TL;DR: The results indicate the need for vigilant monitoring while the patient is receiving ibrutinib therapy, and careful assessment of the risks and benefits of anticoagulation is required.
Journal ArticleDOI
Pharmacotherapy and the risk for community-acquired pneumonia
TL;DR: It was reaffirmed that the use of inhaled corticosteroids and atypical antipsychotics was both associated with an increased risk for CAP in hospitalized older adults of a rural community.