U
Uwe Hobohm
Researcher at Hoffmann-La Roche
Publications - 24
Citations - 2750
Uwe Hobohm is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Cancer & Protein Data Bank. The author has an hindex of 16, co-authored 24 publications receiving 2675 citations. Previous affiliations of Uwe Hobohm include European Bioinformatics Institute & University of Bremen.
Papers
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Selection of representative protein data sets
TL;DR: Two algorithms are developed to extract from the data base representative sets of protein chains with maximum coverage and minimum redundancy and are generally applicable to other data bases in which criteria of similarity can be defined and relate to problems in graph theory.
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Enlarged representative set of protein structures
Uwe Hobohm,Chris Sander +1 more
TL;DR: To reduce redundancy in the Protein Data Bank of 3D protein structures, which is caused by many homologous proteins in the data bank, a representative set of structures is selected to reduce time and effort in statistical analyses.
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Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints.
TL;DR: It is shown here that simply selecting from the sequence database the protein that has the most matching fragment masses often leads to false‐positive results, which is a significant bottleneck for the proteomics work flow.
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A Sequence Property Approach to Searching Protein Databases
Uwe Hobohm,Chris Sander +1 more
TL;DR: This work shows that members of structural protein families have a low mutual PropSearch distance when the weights are optimized to discriminate maximally between structural families, and demonstrates the results of database searches using the PropSearch method.
Journal ArticleDOI
PDBselect 1992–2009 and PDBfilter-select
Sven Griep,Uwe Hobohm +1 more
TL;DR: A list of representative protein chains with low mutual sequence identity selected from the protein data bank to enable unbiased statistics and an online service to generate user-defined selections.