U
Uwe Schmidt
Researcher at Medical University of Vienna
Publications - 19
Citations - 960
Uwe Schmidt is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Bruton's tyrosine kinase & Tyrosine kinase. The author has an hindex of 12, co-authored 18 publications receiving 920 citations.
Papers
More filters
Journal ArticleDOI
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib
Oliver Hantschel,Uwe Rix,Uwe Schmidt,Tilmann Bürckstümmer,Michael Kneidinger,Gregor Schütze,Jacques Colinge,Keiryn L. Bennett,Wilfried Ellmeier,Peter Valent,Giulio Superti-Furga +10 more
TL;DR: The observed inhibition of Tec kinases by dasatinib predicts immunosuppressive (side) effects of this drug and may offer therapeutic opportunities for inflammatory and immunological disorders.
Journal ArticleDOI
Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells
Sebastian Carotta,Sandra Pilat,Andreas Mairhofer,Uwe Schmidt,Helmut Dolznig,Peter Steinlein,Hartmut Beug +6 more
TL;DR: This work describes for the first time an efficient yet easy strategy to generate mass cultures of pure, immature erythroid progenitors from mouse ES cells (ES-EPs), using serum-free medium plus recombinant cytokines and hormones.
Journal ArticleDOI
The Role of Tec Family Kinases in Myeloid Cells
TL;DR: This review summarizes the current knowledge about the function of Tec family kinases in hematopoietic cells of the myeloid lineage.
Journal ArticleDOI
TGF‐β cooperates with TGF‐α to induce the self–renewal of normal erythrocytic progenitors: evidence for an autocrine mechanism
TL;DR: A novel mechanism by which self‐renewal of erythrocytic progenitors is induced is established and avian T2ECs are established as a new, quasi‐optimal model system to study ery Throchic progenitor cells.
Journal ArticleDOI
The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils.
Michael Kneidinger,Uwe Schmidt,Uwe Rix,Karoline V. Gleixner,Anja Vales,Christian Baumgartner,Christian Lupinek,Margit Weghofer,Keiryn L. Bennett,Harald Herrmann,Alexandra Schebesta,Wayne R. Thomas,Susanne Vrtala,Rudolf Valenta,Francis Y. Lee,Wilfried Ellmeier,Giulio Superti-Furga,Peter Valent +17 more
TL;DR: It is reported that dasatinib at 1 microM completely blocks anti-IgE-induced histamine release in blood basophils in healthy donors, and allergen-induced release of histamine in sensitized individuals, and FcepsilonRI-mediated activation of basophil through multiple signaling molecules including Btk is inhibited.